Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AUTORADIOGRAPHIC IDENTIFICATION OF KIDNEY ANGIOTENSIN-IV BINDING-SITES AND ANGIOTENSIN-IV-INDUCED RENAL CORTICAL BLOOD-FLOW CHANGES IN RATS
Autore:
COLEMAN JKM; KREBS LT; HAMILTON TA; ONG B; LAWRENCE KA; SARDINIA MF; HARDING JW; WRIGHT JW;
Indirizzi:
WASHINGTON STATE UNIV,DEPT PSYCHOL,POB 644820 PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT PSYCHOL PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL PULLMAN WA 99164
Titolo Testata:
Peptides
fascicolo: 2, volume: 19, anno: 1998,
pagine: 269 - 277
SICI:
0196-9781(1998)19:2<269:AIOKAB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; RABBIT BRAIN ARTERIOLES; NITRIC-OXIDE; II RECEPTOR; PROXIMAL TUBULE; AT(4) RECEPTORS; CELLS; AUTOREGULATION; PHARMACOLOGY; ANTAGONISTS;
Keywords:
ANGIOTENSIN II; ANGIOTENSIN IV; ANGIOTENSIN ANALOGS; RECEPTOR AUTORADIOGRAPHY; KIDNEY CORTICAL BLOOD FLOW; DUP753; PD123177; DIVALINAL-ANGIV; NITRIC OXIDE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.K.M. Coleman et al., "AUTORADIOGRAPHIC IDENTIFICATION OF KIDNEY ANGIOTENSIN-IV BINDING-SITES AND ANGIOTENSIN-IV-INDUCED RENAL CORTICAL BLOOD-FLOW CHANGES IN RATS", Peptides, 19(2), 1998, pp. 269-277

Abstract

The present investigation initially determined that specific binding sites for the hexapeptide angiotensin TV (AngIV) are present in the rat kidney cortex and outer medulla but not in the inner medulla, using in vitro autoradiographic techniques. This binding site has been termed AT(4), is distinct from the previously characterized AT, and AT, sites, and does not bind the specific AT(1) receptor antagonist DuP753 orthe AT(2) receptor antagonist PD123177. Renal artery infusions of AngIV produced a dose-dependent increase in cortical blood flow without altering systemic blood pressure. In contrast, the infusion of angiotensin II (AngII) induced a dramatic decrease in cortical blood flow, accompanied by a significant elevation in systemic blood pressure. The infusion of [D-Val(1)]AngIV, an analog that does not bind at the AT(4) receptor site, and the C-terminal truncated analogs AngIV (1-4) and AngIV (1-5) that possess lower affinity for this site, produced no changein cortical blood flow. The infusion of [Nle(1)]AngIV and [Lys(1)]AngIV, analogs that bind with high affinity at the AT(4) receptor site, produced increases in cortical blood flow with no influence on blood pressure. Pretreatment with a specific AT(4) receptor antagonist, Divalinal-AngIV, completely blocked AngIV-induced elevations in blood flow, but failed to influence AngII-induced decreases in blood flow, suggesting that these ligands are acting at different receptor sites. Pretreatment with the nitric oxide synthase inhibitor, N-G-Monomethyl-L-Arginine, also blocked subsequent AngIV-induced increases in cortical bloodflow. These data support the notion that AngIV exerts a unique influence upon renal hemodynamics via the AT(4) receptor subtype, and suggest that AngIV-induced elevations in blood flow may be mediated by nitric oxide. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:06:39