Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RESPONSIVENESS OF URINARY MARKERS OF BONE-RESORPTION TO ORCHIECTOMY AND CLODRONATE TREATMENT IN MATURE RATS - A COMPARATIVE-STUDY
Autore:
RUBINACCI A; VILLA I; SIBILIA V; NETTI C; MORO G; PECILE A;
Indirizzi:
UNIV MILAN,DIPARTIMENTO FARMACOL CHEMIOTERAPIA TOSSICOL MED,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,DIPARTIMENTO FARMACOL CHEMIOTERAPIA TOSSICOL MED I-20129 MILAN ITALY SAN RAFFAELE SCI INST,UNITA METAB OSSA I-20132 MILAN ITALY
Titolo Testata:
European journal of endocrinology
fascicolo: 1, volume: 138, anno: 1998,
pagine: 120 - 127
SICI:
0804-4643(1998)138:1<120:ROUMOB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIDINIUM CROSS-LINKS; PERFORMANCE LIQUID-CHROMATOGRAPHY; HYDROXYLYSINE GLYCOSIDES; DICHLOROMETHYLENE BIPHOSPHONATE; BIOCHEMICAL MARKERS; COLLAGEN; EXCRETION; TURNOVER; OVARIECTOMY; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Rubinacci et al., "RESPONSIVENESS OF URINARY MARKERS OF BONE-RESORPTION TO ORCHIECTOMY AND CLODRONATE TREATMENT IN MATURE RATS - A COMPARATIVE-STUDY", European journal of endocrinology, 138(1), 1998, pp. 120-127

Abstract

Objective: The aim of this study was to assess the responsiveness of two classes of bone resorption markers to the enhancement of osteoclastic activity induced by orchiectomy and to its inhibition by clodronate treatment in mature rats, Design: Bone mineral density (BMD) at femural metaphysis, femural diaphysis, lumbar vertebrae, and the urinary excretion of pyridinoline (Pyr), deoxypyridinoline (D-Pyr), galactosylhydroxylysine (GHyl) and glucosylgalactosylhyroxylysine (GGHyl) were monitored at regular intervals for 30 days prior to and for 60 days following orchiectomy in eleven rats, divided into two groups: Eve rats untreated and the other six treated with clodronate. Results: Prior to orchiectomy, a significant (P < 0.01) decrease in BMD was observed onlyat the distal femural metaphysis. This decrease appeared to be associated with a time-dependent increase in the urinary excretion of all markers. Following orchiectomy, the BMD of the untreated group decreasedsignificantly (P < 0.01) at all bone sites. The bone loss was accompanied by a significant (P < 0.01) increase in Pyr and D-Pyr concentrations in mine, whereas urinary GHyl and GGHyl did not change significantly. Ln the clodronate-treated group, the BMD of the three skeletal sites did not change significantly, while the urinary excretion of all urinary biochemical markers decreased significantly (P < 0.001). Conclusion: This study showed that pyridinolines are able to monitor the boneresponse to orchiectomy and to clodronate treatment response in androgen-deficient mature male rat, whereas glycosides appear prone to confounding factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:25:12