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Titolo:
THE ROLE OF PLACENTAL TROPHOBLAST IN THE LIPID PATHOPHYSIOLOGY OF THEANTIPHOSPHOLIPID ANTIBODY SYNDROME
Autore:
ROTE NS; VOGT E; DEVERE G; OBRINGER AR; NG AK;
Indirizzi:
WRIGHT STATE UNIV,SCH MED,DEPT IMMUNOL & MICROBIOL DAYTON OH 45435
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 2, volume: 39, anno: 1998,
pagine: 125 - 136
SICI:
1046-7408(1998)39:2<125:TROPTI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE PHOSPHOLIPID ASYMMETRY; ANTICOAGULANT PROTEIN-I; GONADOTROPIN-RELEASING-HORMONE; FETAL GROWTH-RETARDATION; ANNEXIN-V; LUPUS ANTICOAGULANT; PHYSIOLOGICAL SIGNIFICANCE; DECIDUAL VASCULOPATHY; PLASMA-MEMBRANE; HUMAN-PLATELETS;
Keywords:
ANNEXIN V; ANTIPHOSPHOLIPID ANTIBODIES; CHORIOCARCINOMA; PHOSPHATIDYLSERINE; TROPHOBLAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
N.S. Rote et al., "THE ROLE OF PLACENTAL TROPHOBLAST IN THE LIPID PATHOPHYSIOLOGY OF THEANTIPHOSPHOLIPID ANTIBODY SYNDROME", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 39(2), 1998, pp. 125-136

Abstract

PROBLEM: The antiphospholipid (aPL) antibody syndrome is characterized by severe pregnancy complications, the cause of which remains unknown. We hypothesized that the placental trophoblast is a target for aPLs. METHOD OF STUDY: The effects of monoclonal aPLs on trophoblast function, including the invasion of JAR into matrigel-coated filters and the effects of annexin V expression on BeWo, were investigated using choriocarcinoma models. RESULTS: aPLs against phosphatidylserine (PS) significantly (P < 0.001) decreased the migration of JAR across the membrane. In the annexin V studies, undifferentiated BeWo did not express surface annexin V. After differentiation, BeWo expressed surface annexin V, which was removed in the presence of aPLs, resulting in increasedbinding of prothrombin. CONCLUSIONS: PS is expressed on the trophoblast surface during differentiation and invasion of extracellular matrix. Our data suggest that aPLs against PS can directly affect trophoblast function by limiting the depth of decidual invasion and by concurrently creating a procoagulant surface on trophoblast exposed to the maternal circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:07:37