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Titolo:
ANTIOXIDATIVE PROPERTIES OF ORGANOTELLURIUM COMPOUNDS IN CELL SYSTEMS
Autore:
WIESLANDER E; ENGMAN L; SVENSJO E; ERLANSSON M; JOHANSSON U; LINDEN M; ANDERSSON CM; BRATTSAND R;
Indirizzi:
UNIV UPPSALA,INST CHEM,DEPT ORGAN CHEM,BOX 531 S-75121 UPPSALA SWEDEN UNIV UPPSALA,INST CHEM,DEPT ORGAN CHEM S-75121 UPPSALA SWEDEN ASTRO DRACO AB,PRECLIN R&D S-22100 LUND SWEDEN
Titolo Testata:
Biochemical pharmacology
fascicolo: 5, volume: 55, anno: 1998,
pagine: 573 - 584
SICI:
0006-2952(1998)55:5<573:APOOCI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERT-BUTYL HYDROPEROXIDE; THIOL PEROXIDASE-ACTIVITY; HAMSTER CHEEK POUCH; LIPID-PEROXIDATION; DIARYL TELLURIDES; ENDOTHELIAL-CELLS; RADICALS; INJURY; PERMEABILITY; HEPATOCYTES;
Keywords:
ORGANOTELLURIUM COMPOUNDS; ANTIOXIDANT; LUNG FIBROBLASTS; CACO-2 CELLS; ANOXIA AND REOXYGENATION; ISCHEMIA/REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
E. Wieslander et al., "ANTIOXIDATIVE PROPERTIES OF ORGANOTELLURIUM COMPOUNDS IN CELL SYSTEMS", Biochemical pharmacology, 55(5), 1998, pp. 573-584

Abstract

The protective/antioxidative properties of diaryl tellurides were demonstrated in cellular systems of increasing complexity. In the presence of glutathione, bis(4-hydroxyphenyl) celluride (1a), bis(4-aminophenyl) telluride (1d) and bis(2-carboxyphenyl) telluride (1h) reduced by more than 50% t-butyl hydroperoxide-induced cell death in lung fibroblast cultures at concentrations below 2 mu M Bis(2,6-dimethyl-4-hydroxyphenyl) telluride (2b) reduced by more than 50% leukocyte-mediated andphorbol-12-myristate-13-acetate-stimulated damage to Caco-2 cells at 0.1 mu M concentration. As judged by their abilities to reduce formation of thiobarbituric acid reactive substances at concentrations close to 1 mu M, diaryl tellurides 1a, 1d and 2b protected rat kidney tissueagainst oxidative damage caused by anoxia and reoxygenation. The organotellurium compounds also offered protection after systemic administration. In the presence of diaryl telluride 2b (0.1-1 mu M), the ischemia/reperfusion-induced vascular permeability increase in the hamster cheek pouch was significantly reduced as compared with the control. Some of the most active organotellurium cell protectants were evaluated for their ability to inhibit formation of the inflammatory mediators leukotriene B-4 and interleukin-1 beta. An inhibitory effect on the secretion of these species was seen for compounds 1a and 2b at or above 10mu M concentrations. The protective effects of diaryl tellurides against t-butyl hydroperoxide-induced cell injury can be ascribed mainly to the peroxide-decomposing, glutathione peroxidase-like capacity of the compounds. The chain-breaking, electron-or hydrogen atom-donating ability of diaryl tellurides seems to be the main reason for their protection against leukocyte-mediated cell damage in Caco-2 cells and in the oxidatively challenged rat kidney and hamster cheek pouch. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:41:25