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Titolo:
SURFACTANT PROTEIN-A MEDIATES MYCOPLASMACIDAL ACTIVITY OF ALVEOLAR MACROPHAGES
Autore:
HICKMANDAVIS JM; LINDSEY JR; ZHU S; MATALON S;
Indirizzi:
UNIV ALABAMA,DEPT ANESTHESIOL,SCH MED,619 S 19TH ST BIRMINGHAM AL 35233 UNIV ALABAMA,DEPT COMPARAT MED,SCH MED BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT ANESTHESIOL,SCH MED BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PHYSIOL & BIOPHYS,SCH MED BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PEDIAT,SCH MED BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PEDIAT,SCH DENT BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT ANESTHESIOL,SCH DENT BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT COMMUNITY MED,SCH DENT BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT PHYSIOL & BIOPHYS,SCH DENT BIRMINGHAM AL 35294
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 2, volume: 18, anno: 1998,
pagine: 270 - 277
SICI:
1040-0605(1998)18:2<270:SPMMAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; SP-A; PULMONARY SURFACTANT; MYCOBACTERIUM-TUBERCULOSIS; RESPIRATORY MYCOPLASMOSIS; MURINE MACROPHAGES; GAMMA-INTERFERON; C57BL/6N MICE; NITRIC-OXIDE; C3H-HEN MICE;
Keywords:
NITRIC OXIDE; PEROXYNITRITE; PULMONARY DEFENSES; MYCOPLASMA PULMONIS; OPSONOPHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Hickmandavis et al., "SURFACTANT PROTEIN-A MEDIATES MYCOPLASMACIDAL ACTIVITY OF ALVEOLAR MACROPHAGES", American journal of physiology. Lung cellular and molecular physiology, 18(2), 1998, pp. 270-277

Abstract

Mycoplasma pneumoniae is a leading cause of pneumonia and exacerbatesother respiratory diseases in humans. mie investigated the potential role of surfactant protein (SP) A in antimycoplasmal defense using alveolar macrophages (AMs) from C57BL/6NCr (C57/BL) mice, which are highly resistant to infections of Mycoplasma pulmonis. C57BL AMs, activatedwith interferon (IFN)-gamma and incubated with SP-A (25 mu g/ml) at 37 degrees C, produced significant amounts of nitric oxide (.NO; nitrate and nitrite production = 1.1 mu M . h(-1) . 10(5) AMs(-1)) and effected an 83% decrease in mycoplasma colony-forming units (CFUs) by 6 h postinfection. Preincubation of AMs with the inducible nitric oxide synthase inhibitor N-G-monomethyl-L-arginine abolished .NO production andSP-A-mediated killing of mycoplasmas. No decrease in CFUs was seen when IFN-gamma-activated macrophages were infected with mycoplasmas in the absence of SP-A despite significant .NO production (nitrate and nitrite production = 0.6 mu M . h(-1) . 10(5) AMs(-1)). These results demonstrate that SP-A mediates killing of mycoplasmas by AMs, possibly through an .NO-dependent mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:52:44