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Titolo:
MOLECULAR-CLONING AND LOCALIZATION OF HUMAN SYNTAXIN-16, A MEMBER OF THE SYNTAXIN FAMILY OF SNARE PROTEINS
Autore:
TANG BL; LOW DYH; LEE SS; TAN AEH; HONG WJ;
Indirizzi:
INST MOL & CELL BIOL,MEMBRANE BIOL LAB,30 MED DR SINGAPORE 117609 SINGAPORE INST MOL & CELL BIOL,MEMBRANE BIOL LAB SINGAPORE 117609 SINGAPORE
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 242, anno: 1998,
pagine: 673 - 679
SICI:
0006-291X(1998)242:3<673:MALOHS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTEGRAL MEMBRANE-PROTEIN; BREFELDIN-A; CIS-GOLGI; TRANSPORT; TRAFFICKING; RECEPTORS; APPARATUS; VESICLES; DYNAMICS; NETWORK;
Keywords:
SYNTAXIN; SNARE; PROTEIN TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Tang et al., "MOLECULAR-CLONING AND LOCALIZATION OF HUMAN SYNTAXIN-16, A MEMBER OF THE SYNTAXIN FAMILY OF SNARE PROTEINS", Biochemical and biophysical research communications, 242(3), 1998, pp. 673-679

Abstract

We have cloned a new member of the syntaxin family of proteins, designated human syntaxin 16 (hsyn16), The open reading frame encodes a polypeptide of 307 amino acids with potential coiled-coil domains and a carboxy-terminal hydrophobic tail, which is characteristic of other members of the syntaxin family. The encoded polypeptide bears sequence homology to known syntaxin molecules. Northern blot analysis revealed a single transcript that is fairly ubiquitous, being slightly more more enriched in heart and pancreas, Indirect immunofluorescence localised myc-tagged hsyn16 (myc-hsyn16) to the Golgi apparatus, colocalizing well with lens culinaris agglutinin, an established Gels marker, as wellas with other Gels SNAREs such as GS28 and syntaxin 5. Myc-hsyn16 is redistributed to the endoplasmic reticulum upon brefeldin A treatment,indicating that it is localised to the Gels stack. The ubiquitous expression and Golgi localization of hsy16 suggest that it is involved ina vesicular transport step within the organelle. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:38:17