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Titolo:
EXPRESSION AND TYROSINE PHOSPHORYLATION OF EPH RECEPTORS SUGGEST MULTIPLE MECHANISMS IN PATTERNING OF THE VISUAL-SYSTEM
Autore:
CONNOR RJ; MENZEL P; PASQUALE EB;
Indirizzi:
BURNHAM INST,10901 N TORREY PINES RD LA JOLLA CA 92037
Titolo Testata:
Developmental biology
fascicolo: 1, volume: 193, anno: 1998,
pagine: 21 - 35
SICI:
0012-1606(1998)193:1<21:EATPOE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXONAL GUIDANCE MOLECULE; CHICK OPTIC TECTUM; RETINAL AXONS; RETINOTECTAL TOPOGRAPHY; KINASE-ACTIVITY; PROJECTION MAP; MESSENGER-RNAS; CELL-ADHESION; NEURAL RETINA; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Connor et al., "EXPRESSION AND TYROSINE PHOSPHORYLATION OF EPH RECEPTORS SUGGEST MULTIPLE MECHANISMS IN PATTERNING OF THE VISUAL-SYSTEM", Developmental biology, 193(1), 1998, pp. 21-35

Abstract

The EphA3 receptor tyrosine kinase has been implicated in guiding theaxons of retinal ganglion cells as they extend in the optic tectum. Arepulsive mechanism involving opposing gradients of the EphA3 receptor on retinal axons and its Ligands, ephrin-A2 and ephrin-A5, in the tectum influences topographic mapping of the retinotectal projection. Toinvestigate the overall role of the Eph family in patterning of the visual system, we have used in situ hybridization to localize nine Eph receptors in the chicken retina and optic tectum at Embryonic Day 8. Three of the receptors examined correspond to the novel chicken homologs of EphA2, EphA6, and EphA7. Unexpectedly, we found that many Eph receptors are expressed not only in retinal ganglion cells, but also in tectal cells. In particular, EphA3 mRNA is prominently expressed in theanterior tectum, with a pattern reciprocal to that of ephrin-A2 and ephrin-A5. Similarly, ephrin-A5 is expressed not only in tectal cells but also in the nasal retina, with a pattern reciprocal to that of its receptor EphA3 and partially overlapping with that of its other receptor EphA4. Consistent with the even distribution of EphA4 and the polarized distribution of EphA4 Ligands in the retina, probing EphA4 immunoprecipitates from different sectors of the retina with anti-phosphotyrosine antibodies revealed spatial differences in receptor phosphorylation. These complex patterns of expression and tyrosine phosphorylationsuggest that Eph receptors and ephrins contribute to establishing topography of retinal axons through multiple mechanisms, in addition to playing a role in intraretinal and intratectal organization. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 08:59:15