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Titolo:
EFFECTS OF SEX STEROIDS ON PLASMA TOTAL HOMOCYSTEINE LEVELS - A STUDYIN TRANSSEXUAL MALES AND FEMALES
Autore:
GILTAY EJ; HOOGEVEEN EK; ELBERS JMH; GOOREN LJG; ASSCHEMAN H; STEHOUWER CDA;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT ENDOCRINOL,DIV ANDROL,POB 7057 NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT ENDOCRINOL,DIV ANDROL NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,INST RES EXTRAMURAL MED NL-1007 MB AMSTERDAMNETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,INST CARDIOVASC RES NL-1007 MB AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM NL-1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 2, volume: 83, anno: 1998,
pagine: 550 - 553
SICI:
0021-972X(1998)83:2<550:EOSSOP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; ORAL-CONTRACEPTIVES; SERUM HOMOCYSTEINE; RISK FACTOR; THERAPY; DISEASE; HOMOCYST(E)INE; DETERMINANTS; COBALAMIN; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Giltay et al., "EFFECTS OF SEX STEROIDS ON PLASMA TOTAL HOMOCYSTEINE LEVELS - A STUDYIN TRANSSEXUAL MALES AND FEMALES", The Journal of clinical endocrinology and metabolism, 83(2), 1998, pp. 550-553

Abstract

Plasma total homocysteine (tHcy) levels are higher in men vs. premenopausal women, but it is not known whether this difference is related to sex steroids. The effects of cross-sex hormone administration on plasma tHcy levels were therefore investigated. Plasma tHcy levels were measured at baseline and after 4 months of treatment in 17 male-to-female (M-->F) transsexuals treated with ethinyl estradiol (100 mu g/day),in combination with the antiandrogen, cyproterone acetate (100 mg/day), and in 17 female-to-male (F-->M) transsexuals treated with testosterone esters (250 mg/2 weeks, im). In M-->F transsexuals, the plasma tHcy level decreased from geometric mean 8.2 mu mol/L to 5.7 mu mol/L (P< 0.001); and in F-->M transsexuals, it increased from 7.7 mu mol/L to 9.0 mu mol/L (P = 0.005). In M-->F transsexuals, changes in serum sex hormone-binding globulin levels correlated negatively, and changes in plasma creatinine and albumin levels correlated positively, with changes in plasma tHcy levels. In F-->M transsexuals, changes in serum 17beta-estradiol levels correlated negatively, and changes in plasma creatinine levels correlated positively, with changes in plasma tHcy levels. We conclude that tHcy levels decrease after estrogen + antiandrogen administration to male (transsexual) subjects, and levels increase after androgen administration to female (transsexual) subjects. These changes may be both primary and secondary to the anabolic/catabolic effects, as reflected by changes of creatinine and albumin levels after cross-sex hormone administration.

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Documento generato il 03/12/20 alle ore 15:55:40