Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCREASED LEVELS AND PULSATILITY OF FOLLICLE-STIMULATING-HORMONE IN MOTHERS OF HEREDITARY DIZYGOTIC TWINS
Autore:
LAMBALK CB; BOOMSMA DI; DEBOER L; DEKONING CH; SCHOUTE E; POPPSNIJDERS C; SCHOEMAKER J;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT OBSTET & GYNAECOL,POB 7057 NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,RES INST ENDOCRINOL REPROD & METAB,DIV REPROD ENDOCRINOL NL-1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,FAC PSYCHOL,DEPT PSYCHONOM NL-1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 2, volume: 83, anno: 1998,
pagine: 481 - 486
SICI:
0021-972X(1998)83:2<481:ILAPOF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; LUTEINIZING-HORMONE; OVARIAN-FUNCTION; DIMERIC INHIBIN; OVULATION; FSH; WOMEN; LH; SECRETION; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
C.B. Lambalk et al., "INCREASED LEVELS AND PULSATILITY OF FOLLICLE-STIMULATING-HORMONE IN MOTHERS OF HEREDITARY DIZYGOTIC TWINS", The Journal of clinical endocrinology and metabolism, 83(2), 1998, pp. 481-486

Abstract

According to the endocrine model of hereditary dizygotic twinning, high FSH is responsible for multiple ovulation and pregnancy. Our study explored the underlying neuroendocrine causes. In a prospective clinical study, we compared the third day of menses parameters of episodic secretion of LH and FSH, the pituitary response to LHRH, plasma estradiol, and dimeric inhibin A and B in 16 regularly menstruating and 9 postmenopausal mothers of dizygotic twins with a family history of twinning and 14 premenopausal and 9 postmenopausal controls. Seven of 16 premenopausal mothers of twins had abnormally high FSH levels of more than 10 IU/L compared with 1/14 in controls (P = 0.024). In the premenopausal mothers of twins, mean FSH concentrations (P = 0.025) and FSH pulse frequency (P = 0.003) were significantly elevated, whereas FSH pulse amplitude and FSH response to LHRH were unaltered. For LH, neither the secretory parameters nor the response to LHRH was different. There were no differences between estradiol and inhibin A and B levels. Postmenopausal mothers of twin and controls did not differ with respect tothe secretory pattern of LH and FSH. We Conclude that under equal ovarian feedback conditions, premenopausal mothers of a dizygotic twin have hyper stimulation by endogenous FSH caused by neuroendocrine, hypothalamic, or pituitary mechanisms. This is the result of altered responsiveness to ovarian feedback and/or pituitary or suprapituitary, non-LHRH-like mechanisms that stimulate pulsatile FSH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:06:16