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Titolo:
CHRONIC N-3 POLYUNSATURATED FATTY-ACID DIET-DEFICIENCY ACTS ON DOPAMINE METABOLISM IN THE RAT FRONTAL-CORTEX - A MICRODIALYSIS STUDY
Autore:
ZIMMER L; HEMBERT S; DURAND G; BRETON P; GUILLOTEAU D; BESNARD JC; CHALON S;
Indirizzi:
FAC PHARM TOURS,LAB BIOPHYS MED & PHARMACEUT,INSERM U316,31 AVE MONGEF-37200 TOURS FRANCE FAC PHARM TOURS,LAB BIOPHYS MED & PHARMACEUT,INSERM U316 F-37200 TOURS FRANCE INRA,LAB NUTR & SECUR ALIMENTAIRE JOUY EN JOSAS FRANCE CEB,NEUROPHARMACOL LAB,DGA VERT LE PETIT FRANCE
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 240, anno: 1998,
pagine: 177 - 181
SICI:
0304-3940(1998)240:3<177:CNPFDA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-LINOLENIC ACID; SEROTONINERGIC NEUROTRANSMISSION; COGNITIVE FUNCTIONS; PREFRONTAL CORTEX; TYRAMINE; NEURONS; RELEASE; BRAIN; CELLS;
Keywords:
DOPAMINE; DOPAMINE METABOLITES; FRONTAL CORTEX; N-3 POLYUNSATURATED FATTY ACID; MICRODIALYSIS; TYRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
L. Zimmer et al., "CHRONIC N-3 POLYUNSATURATED FATTY-ACID DIET-DEFICIENCY ACTS ON DOPAMINE METABOLISM IN THE RAT FRONTAL-CORTEX - A MICRODIALYSIS STUDY", Neuroscience letters, 240(3), 1998, pp. 177-181

Abstract

The effects of ol-linolenic acid diet deficiency on rat dopaminergic metabolism were investigated in the frontal cortex of male 2-3 month-old rats using the microdialysis method. Increased basal levels of dopamine metabolites were observed in the frontal cortex of awake deficient rats, without modification of dopamine levels. Moreover, using KCI perfusion which releases newly synthesized dopamine, no difference was observed in anaesthetized deficient rats versus control rats. In addition, a decrease in dopamine release was observed in anaesthetized deficient rats versus control rats after tyramine stimulation, which is known to induce release of dopamine from vesicular stores. A working model is proposed which suggests that a chronic n-3 polyunsatured fatty acids (PUFA) deficiency may lead to modifications in the internalization of dopamine in the storage pool in the frontal cortex. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:49:24