Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SERUM AND MUCOSAL ANTIBODY ISOTYPE RESPONSES TO M-LIKE PROTEIN (SEM) OF STREPTOCOCCUS-EQUI IN CONVALESCENT AND VACCINATED HORSES
Autore:
SHEORAN AS; SPONSELLER BT; HOLMES MA; TIMONEY JF;
Indirizzi:
UNIV KENTUCKY,GLUCK EQUINE RES CTR,DEPT VET SCI LEXINGTON KY 40546 UNIV KENTUCKY,GLUCK EQUINE RES CTR,DEPT VET SCI LEXINGTON KY 40546 UNIV CALIF DAVIS,SCH VET MED,DEPT MED & EPIDEMIOL DAVIS CA 95616 UNIV CAMBRIDGE,DEPT CLIN VET MED CAMBRIDGE CB3 0ES ENGLAND
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3-4, volume: 59, anno: 1997,
pagine: 239 - 251
SICI:
0165-2427(1997)59:3-4<239:SAMAIR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCLASS RESTRICTION; IMMUNOGLOBULIN-G; MONOCLONAL-ANTIBODIES; IMMUNE-COMPLEXES; INFECTION; COMPLEMENT; ANTIGENS; DISEASE; FOALS; VIRUS;
Keywords:
STREPTOCOCCUS EQUI; SEM; IGA; IGG SUBISOTYPES; COMMERCIAL VACCINE; MUCOSAL IMMUNE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Sheoran et al., "SERUM AND MUCOSAL ANTIBODY ISOTYPE RESPONSES TO M-LIKE PROTEIN (SEM) OF STREPTOCOCCUS-EQUI IN CONVALESCENT AND VACCINATED HORSES", Veterinary immunology and immunopathology, 59(3-4), 1997, pp. 239-251

Abstract

Equine strangles, caused by the clonal pathogen Streptococcus equi, is a source of serious economic loss despite the widespread use of commercial vaccines. The anti-phagocytic 58 kDa M-like protein (SeM) is animportant protective antigen. The objective of this study was to define differences, if any, between SeM-specific convalescent serum and mucosal IgA and IgG subisotypes and those induced by vaccination with commercial strangles vaccine. SeM-specific opsonophagocytic IgGb was thepredominant serum antibody in horses intramuscularly vaccinated or recently recovered from infection. Infection also induced high levels ofspecific opsonophagocytic serum IgGa during and shortly after S. equiinfection whereas vaccination stimulated only low levels of serum IgGa. Specific serum IgGc and opsonophagocytic IgA were present at very low levels following infection or vaccination. A strong specific mucosal antibody response occurred during the acute and convalescent phases of infection whereas vaccinated horses made no mucosal response. Specific IgGb was generally predominant in nasopharyngeal washings during the acute phase but was replaced by specific IgA during convalescence. SeM-specific mucosal IgGa and IgG(T) but not IgGc were detected only during the acute and early convalescent phase. The results therefore indicate that vaccination, although inducing SeM-specific serum isotype responses qualitatively and quantitatively similar to those seen in convalescence, did not induce mucosal responses. This suggests that mucosal immunity may be important in acquired resistance to strangles. (C)1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 22:17:24