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Titolo:
POTENT SUPPRESSIVE ACTIVITY OF NONPOLYPHENOLIC FRACTION OF GREEN TEA (CAMELLIA-SINENSIS) AGAINST GENOTOXIN-INDUCED UMU-C GENE-EXPRESSION INSALMONELLA-TYPHIMURIUM (TA-1535 PSK-1002), TUMOR PROMOTOR-DEPENDENT ORNITHINE DECARBOXYLASE INDUCTION OF BALB C 3T3 FIBROBLAST CELLS, AND CHEMICALLY-INDUCED MOUSE SKIN TUMORIGENESIS/
Autore:
OKAI Y; HIGASHIOKAI K;
Indirizzi:
OSAKA KUN EI WOMENS COLL,DEPT HUMAN LIFE SCI,SHOWA KU OSAKA 566 JAPAN
Titolo Testata:
Teratogenesis, carcinogenesis, and mutagenesis
fascicolo: 6, volume: 17, anno: 1997,
pagine: 305 - 312
SICI:
0270-3211(1997)17:6<305:PSAONF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLOROPHYLLIN;
Keywords:
NONPOLYPHENOLIC FRACTION; GREEN TEA; ANTICARCINOGENIC ACTIVITY; TUMOR INITIATION AND PROMOTION; ORNITHINE DECARBOXYLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Okai e K. Higashiokai, "POTENT SUPPRESSIVE ACTIVITY OF NONPOLYPHENOLIC FRACTION OF GREEN TEA (CAMELLIA-SINENSIS) AGAINST GENOTOXIN-INDUCED UMU-C GENE-EXPRESSION INSALMONELLA-TYPHIMURIUM (TA-1535 PSK-1002), TUMOR PROMOTOR-DEPENDENT ORNITHINE DECARBOXYLASE INDUCTION OF BALB C 3T3 FIBROBLAST CELLS, AND CHEMICALLY-INDUCED MOUSE SKIN TUMORIGENESIS/", Teratogenesis, carcinogenesis, and mutagenesis, 17(6), 1997, pp. 305-312

Abstract

Many experimental studies for anticarcinogenic activity of green tea (Camellia sinensis) and tea-derived polyphenols have been carried out. However, the anticarcinogenic activity of the nonpolyphenolic fraction of green tea has been poorly elucidated. To study this problem, the effect of the nonpolyphenolic fraction of green tea leaves was analyzed using in vitro and in vivo experiments associated with tumor initiation and promotion as follows: 1) The nonpolyphenolic fraction caused astrong suppressive effect on umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) induced by genotoxic substances such as 2-amino-6-methyldipirido[1,2 a:3',2'-d]imidazole (Glu-P-1) and 2-aminoanthracene (2-AA) in the presence of a hepatic metabolizing enzyme mixture. 2) The same fraction showed a dose-dependent inhibition of ornithine decarboxylase (ODC) in BALB/c 3T3 fibroblasts induced by a tumor promotor, 12-O-tetradecanoylphorbol-13-acetate (TPA). 3) The same fraction also exhibited a significant suppression against mouse skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) (initiator) andTPA (promotor) through inhibition at both stages of tumor initiation and promotion. These results suggest that the nonpolyphenolic fractionof green tea has a potent suppressing activity against carcinogenesisassociated with tumor initiation and promotion. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 05/12/20 alle ore 01:57:23