Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HEPATITIS-G VIRUS-INFECTION IN CHRONIC LIVER-DISEASE
Autore:
GUILERA M; SAIZ JC; LOPEZLABRADOR FX; OLMEDO E; AMPURDANES S; FORNS X; BRUIX J; PARES A; SANCHEZTAPIAS JM; DEANTA MTJ; RODES J;
Indirizzi:
HOSP CLIN BARCELONA,LIVER UNIT,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,SCH MED,DEPT MED,HOSP CLIN,SERV MICROBIOL E-08036 BARCELONA SPAIN UNIV BARCELONA,SCH MED,DEPT MED,LIVER UNIT E-08036 BARCELONA SPAIN
Titolo Testata:
Gut
fascicolo: 1, volume: 42, anno: 1998,
pagine: 107 - 111
SICI:
0017-5749(1998)42:1<107:HVICL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; C INFECTION; ASSOCIATION; TRANSFUSION;
Keywords:
CHRONIC LIVER DISEASE; HEPATITIS G VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Guilera et al., "HEPATITIS-G VIRUS-INFECTION IN CHRONIC LIVER-DISEASE", Gut, 42(1), 1998, pp. 107-111

Abstract

Background-The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but therole of this agent in chronic liver disease is poorly understood. Aims-To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects-Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods-HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5' non-coding region of HCV and hybridisation to a specific probe. The mainfeatures of HGV RNA seropositive and seronegative patients were compared. Results-The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than noninfected patients but no differences concerning sex, possible sourceof infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions-The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related tochronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:32:05