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Titolo:
MYOCARDIAL FLOW RESERVE IN LONG-TERM SURVIVORS OF REPAIR OF ANOMALOUSLEFT CORONARY-ARTERY FROM PULMONARY-ARTERY
Autore:
SINGH TP; DICARLI MF; SULLIVAN NM; LEONEN MF; MORROW WR;
Indirizzi:
CHILDRENS HOSP MICHIGAN,PET CTR,3901,BEAUBIEN BLVD DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT RADIOL DETROIT MI 48202 WAYNE STATE UNIV,SCH MED,DEPT MED,DIV CARDIOL DETROIT MI 48202 WAYNE STATE UNIV,SCH MED,DEPT PEDIAT,DIV PEDIAT CARDIOL DETROIT MI 48202
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 2, volume: 31, anno: 1998,
pagine: 437 - 443
SICI:
0735-1097(1998)31:2<437:MFRILS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; LEFT-VENTRICULAR FUNCTION; BLOOD-FLOW; N-13 AMMONIA; INTACT DOGS; PERFUSION; ORIGIN; STENOSIS; QUANTIFICATION; DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Singh et al., "MYOCARDIAL FLOW RESERVE IN LONG-TERM SURVIVORS OF REPAIR OF ANOMALOUSLEFT CORONARY-ARTERY FROM PULMONARY-ARTERY", Journal of the American College of Cardiology, 31(2), 1998, pp. 437-443

Abstract

Objectives. This study sought to evaluate regional myocardial how reserve in long-term survivors of repair of anomalous left coronary artery from pulmonary artery (ALCAPA) and to relate the flow abnormalities to the patients' exercise performance. Background. Patients with ALCAPA usually present during infancy with severe ischemic cardiomyopathy. The left ventricular function recovers after surgical repair, However,the extent of recovery of myocardial blood how (MBF) and its potential physiologic significance in long-term survivors are unknown. Methods. We evaluated MBF (ml/g per min) at baseline and during maximal coronary vasodilation by adenosine in 11 patients after ALCAPA repair (median age 17 years, range 7 to 22) using nitrogen-13 ammonia and dynamic positron emission tomographic imaging. Patients also underwent an incremental exercise test with metabolic monitoring. In each patient, MBP was quantified in the three major vascular territories: the left anterior descending and left circumflex coronary artery territories and theright coronary artery (control region) territory. Results. Basal MBF was mildly reduced in the left coronary territories versus the controlregion (0.79 +/- 0.14 vs, 0.85 +/- 0.19, p = 0.05), During hyperemia,flow in the left coronary territories was significantly lower than that in the control region (2.1 +/- 0.5 vs. 2.6 +/- 0.5, p < 0.001). As a result, myocardial flow reserve was lower in the left coronary territories than in the control region (2.6 +/- 0.7 vs. 3.2 +/- 0.7, p < 0.001). Exercise performance was impaired in patients when compared withage-matched control subjects, Maximal oxygen consumption correlated linearly with maximal hyperemic hows in the left coronary artery territories (r = 0.73, p = 0.03). Conclusions. Long-term survivors of ALCAPArepair demonstrate regional impairment of myocardial flow reserve. This may contribute to impaired exercise performance by limiting cardiacoutput reserve. (C) 1998 by the American College of Cardiology.

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Documento generato il 22/01/20 alle ore 12:33:36