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Titolo:
INTERLEUKIN-6 SPILLOVER IN THE PERIPHERAL-CIRCULATION INCREASES WITH THE SEVERITY OF HEART-FAILURE, AND THE HIGH PLASMA-LEVEL OF INTERLEUKIN-6 IS AN IMPORTANT PROGNOSTIC PREDICTOR IN PATIENTS WITH CONGESTIVE-HEART-FAILURE
Autore:
TSUTAMOTO T; HISANAGA T; WADA A; MAEDA K; OHNISHI M; FUKAI D; MABUCHI N; SAWAKI M; KINOSHITA M;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 52021 JAPAN
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 2, volume: 31, anno: 1998,
pagine: 391 - 398
SICI:
0735-1097(1998)31:2<391:ISITPI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ATRIAL-NATRIURETIC-PEPTIDE; ENDOTHELIAL-CELLS; CYTOKINES; IL-6; MEDIATION; ATROPHY; ALPHA; BSF-2; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Tsutamoto et al., "INTERLEUKIN-6 SPILLOVER IN THE PERIPHERAL-CIRCULATION INCREASES WITH THE SEVERITY OF HEART-FAILURE, AND THE HIGH PLASMA-LEVEL OF INTERLEUKIN-6 IS AN IMPORTANT PROGNOSTIC PREDICTOR IN PATIENTS WITH CONGESTIVE-HEART-FAILURE", Journal of the American College of Cardiology, 31(2), 1998, pp. 391-398

Abstract

Objectives. We 1) evaluated whether interleukin-6 (IL-6) is produced in the peripheral circulation in patients,vith congestive heart failure (CHF), 2) estimated the factors for increased IL-6, and 3) clarifiedthe prognostic role of high plasma levels of IL-6 in patients with CHF. Background. Although plasma levels of IL-6 have been reported to increase in patients with CHF, and production of IL-6 in endothelial cells and vascular smooth muscle cells has been postulated from in vitro studies, the origin of the increase of IL-6 in CHF remains unknown. Moreover, the prognostic value of a high plasma level of IL-6, independent of classic neurohumoral factors, remains to be elucidated. Methods. A comparison was made of the plasma levels of IL-6 between the femoral artery and the femoral vein in 13 normal subjects and in 80 patientswith CHP. In another study, we measured plasma IL-6 in 100 patients with CHF and follow-up data. Results. Plasma IL-S levels increased significantly from the femoral artery to the femoral vein in normal subjects and in patients with CHF. Arteriovenous IL-6 spillover in the leg increased with the severity of CHF. Among the hemodynamic variables andthe various neurohumoral factors, the plasma norepinephrine (NE) level shelved an independent and significant positive relation with the plasma IL-6 level in patients with CHF. Moreover, treatment with beta-adrenergic blocking agents showed an independent and significant negative relation with plasma IL-6 levels. In 100 patients, plasma IL-6 (p < 0.0001), NE (p = 0.0004) and left ventricular ejection fraction (0.015) were significant independent prognostic predictors by Cox proportional hazards analysis. (C) 1998 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 08:07:08