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Titolo:
ABSENCE OF HUMAN PLACENTAL-LACTOGEN AND PLACENTAL GROWTH-HORMONE (HGH-V) DURING PREGNANCY - PCR ANALYSIS OF THE DELETION
Autore:
RYGAARD K; REVOL A; ESQUIVELESCOBEDO D; BECK BL; BARRERASALDANA HA;
Indirizzi:
UNIV AUTONOMA DE NUEVO LEON,FAC MED,DEPT BIOQUIM,APDO POSTAL 3-4125 MONTERREY 64460 NL MEXICO UNIV AUTONOMA DE NUEVO LEON,FAC MED,DEPT BIOQUIM MONTERREY 64460 NL MEXICO UNIV COPENHAGEN,INST MOL PATHOL DK-2100 COPENHAGEN DENMARK FREDERIKSBERG UNIV HOSP,DEPT OBSTET & GYNAECOL DK-2000 FREDERIKSBERG DENMARK UNIV COPENHAGEN,RIGSHOSP,DEPT PATHOL DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Human genetics
fascicolo: 1, volume: 102, anno: 1998,
pagine: 87 - 92
SICI:
0340-6717(1998)102:1<87:AOHPAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC SOMATOMAMMOTROPIN; GENE DELETION; VARIANT; DEFICIENCY; POLYMERASE; EVOLUTION; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Rygaard et al., "ABSENCE OF HUMAN PLACENTAL-LACTOGEN AND PLACENTAL GROWTH-HORMONE (HGH-V) DURING PREGNANCY - PCR ANALYSIS OF THE DELETION", Human genetics, 102(1), 1998, pp. 87-92

Abstract

Human placental lactogen (HPL) is produced in large amounts in normalpregnancies. We report a pregnancy with complete lack of HPL and the placental variant of the human growth hormone HGH-V, The pregnancy resulted in a severely growth-retarded but otherwise normal male baby. PCR analysis of DNA extracted from the placenta showed that the HPL encoding genes hPL-4 and hPL-3 were deleted along with the human growth hormone variant gene (hGH-V), which is located between these two active hPL genes and also expressed in the normal placenta. Of the five members of this multigene family, hGH-N, which is expressed in the pituitary gland, and hPL-1, a presumed pseudogene, were left intact. The latter (hPL-1) was expressed as RNA transcripts only at very low levels as is usually reported in normal pregnancies. Analysis of the parents' DNA showed that both of them carried a different heterozygous deletion at the 3' end of the hGH/hPL locus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:59:11