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Titolo:
MODULATION OF HIPPOCAMPAL ACETYLCHOLINE-RELEASE AND SPONTANEOUS-ALTERNATION SCORES BY INTRAHIPPOCAMPAL GLUCOSE INJECTIONS
Autore:
RAGOZZINO ME; PAL SN; UNICK K; STEFANI MR; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
The Journal of neuroscience
fascicolo: 4, volume: 18, anno: 1998,
pagine: 1595 - 1601
SICI:
0270-6474(1998)18:4<1595:MOHAAS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFINITY CHOLINE UPTAKE; MORPHINE INJECTIONS; INVIVO MICRODIALYSIS; MEDIAL SEPTUM; IN-VIVO; MEMORY; RAT; BRAIN; ATTENUATION; ENHANCEMENT;
Keywords:
GLUCOSE; MEMORY; LEARNING; HIPPOCAMPUS; ACETYLCHOLINE; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino et al., "MODULATION OF HIPPOCAMPAL ACETYLCHOLINE-RELEASE AND SPONTANEOUS-ALTERNATION SCORES BY INTRAHIPPOCAMPAL GLUCOSE INJECTIONS", The Journal of neuroscience, 18(4), 1998, pp. 1595-1601

Abstract

Recent evidence indicates that systemic glucose treatment enhances memory while producing a corresponding increase in hippocampal acetylcholine (ACh) output. The present experiments examined whether unilateralintrahippocampal infusions of glucose would enhance spontaneous alternation performance and whether there would be a corresponding increasein ACh output in the ipsilateral and contralateral hippocampus. Extracellular ACh was assessed in samples collected at 12 min intervals using in vivo microdialysis with HPLC with electrochemical detection. Twelve minutes after a unilateral infusion of artificial cerebrospinal fluid (CSF) or glucose (6.6 mM), rats were tested in a cross maze for spontaneous alternation behavior with concurrent microdialysis collection, In two experiments, glucose infusions significantly increased alternation scores (67.5 and 59%) compared with CSF controls (42.4 and 39.5%, respectively), In both experiments, behavioral testing resulted in increased ACh output in the hippocampus. Glucose administration at thelime of alternation tests enhanced ACh output beyond that of behavioral testing alone both ipsilateral (+93.8%) and contralateral (+85%) tothe infusion site, as compared with ACh output (+36.1% and +55.5%) ofCSF controls, Glucose infusions did not affect hippocampal ACh outputin rats kept in a holding chamber. These results suggest that glucosemay enhance alternation scores by modulating ACh release, The findings also indicate that unilateral glucose infusions increase hippocampalACh output both ipsilateral and contralateral to the site of injection, Furthermore, glucose increased ACh output only during maze testing,suggesting that specific behavioral demands, perhaps requiring activation of cholinergic neurons, determine the efficacy of glucose in modulating ACh release.

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Documento generato il 12/07/20 alle ore 06:40:29