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Titolo:
NATURAL-HISTORY OF CERVICOVAGINAL PAPILLOMAVIRUS INFECTION IN YOUNG-WOMEN
Autore:
HO GYF; BIERMAN R; BEARDSLEY L; CHANG CJ; BURK RD;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,ALBERT EINSTEIN CANC CTR,1300 MORRIS PK AVE,ULLMANN BLDG BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,ALBERT EINSTEIN CANC CTR BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 RUTGERS STATE UNIV,STUDENT HLTH SERV NEW BRUNSWICK NJ 08903
Titolo Testata:
The New England journal of medicine
fascicolo: 7, volume: 338, anno: 1998,
pagine: 423 - 428
SICI:
0028-4793(1998)338:7<423:NOCPII>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENITAL HUMAN PAPILLOMAVIRUS; CYTOLOGICALLY NORMAL WOMEN; TERM FOLLOW-UP; CERVICAL-CANCER; RISK-FACTORS; LONGITUDINAL DATA; PREVALENCE; DYSPLASIA; BEHAVIOR; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G.Y.F. Ho et al., "NATURAL-HISTORY OF CERVICOVAGINAL PAPILLOMAVIRUS INFECTION IN YOUNG-WOMEN", The New England journal of medicine, 338(7), 1998, pp. 423-428

Abstract

Background Genital human papillomavirus (HPV) infection is highly prevalent in sexually active young women. However, precise risk factors for HPV infection and its incidence and duration are not well known. Methods We followed 608 college women at six-month intervals for three years. At each visit, we collected information about lifestyle and sexual behavior and obtained cervicovaginal-lavage samples for the detection of HPV DNA by polymerase chain reaction and Southern blot hybridization. Pap smears were obtained annually. Results The cumulative 36-month incidence of HPV infection was 43 percent (95 percent confidence interval, 36 to 49 percent). An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race,an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristicsof partners (regular partners having an increased number of lifetime partners and not being in school). The median duration of new infections was 8 months (95 percent confidence interval, 7 to 10 months). The persistence of HPV for greater than or equal to 6 months was related to older age, types of HPV associated with cervical cancer, and infection with multiple types of HPV but not with smoking. The risk of an abnormal Pap smear increased with persistent HPV infection, particularly with high-risk types (relative risk, 37.2; 95 percent confidence interval, 14.6 to 94.8). Conclusions The incidence of HPV infection in sexually active young college women is high. The short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively. (C) 1998, Massachusetts Medical Society.

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Documento generato il 27/01/21 alle ore 09:40:42