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Titolo:
SODIUM-TRANSPORT AND BONE-MINERAL DENSITY IN HYPERCALCIURIA WITH THIAZIDE TREATMENT
Autore:
REUSZ GS; DOBOS M; VASARHELYI B; SALLAY P; SZABO A; HORVATH C; SZABO A; BYRD DJ; THOLE HH; TULASSAY T;
Indirizzi:
SEMMELWEIS UNIV MED SCH,DEPT PEDIAT 1,BOKAY J U 53 H-1083 BUDAPEST HUNGARY
Titolo Testata:
Pediatric nephrology
fascicolo: 1, volume: 12, anno: 1998,
pagine: 30 - 34
SICI:
0931-041X(1998)12:1<30:SABDIH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM EXCRETION; IDIOPATHIC HYPERCALCIURIA; LITHIUM COUNTERTRANSPORT; ESSENTIAL-HYPERTENSION; CHILDREN; HYDROCHLOROTHIAZIDE; HEMATURIA;
Keywords:
HYPERCALCIURIA; NA+/K+-ATPASE; NA+/LI+ COUNTERTRANSPORT; THIAZIDES; BONE MINERAL DENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Reusz et al., "SODIUM-TRANSPORT AND BONE-MINERAL DENSITY IN HYPERCALCIURIA WITH THIAZIDE TREATMENT", Pediatric nephrology, 12(1), 1998, pp. 30-34

Abstract

Erythrocyte sodium-potassium (Na+/K+) -ATPase and sodium-lithium (Na+/Li+) countertransport activities were measured in 18 children (aged 9.6 years, range 6-16 years) with idiopathic hypercalciuria (IHU) to evaluate cellular Na handling. The effect of chronic thiazide administration on these parameters and on bone mineral density was also evaluated. Patients with IHU had significantly lower erythrocyte Na+/K+-ATPaseactivity than 23 age-matched healthy controls (mean + SEM 2,156 +/- 110 mu mol P/l erythrocyte per hour vs. 3,165 +/- 175, P < 0.01). Thiazide treatment significantly lowered urinary calcium excretion; this was followed by a slight suppression of intact parathyroid hormone (iPTH). The urinary calcium/creatinine ratio before and during treatment was 0.90 +/- 0.07 mmol/mmol versus 0.51 +/- 0.06 respectively, P < 0.01. The corresponding iPTH levels were 5.9 +/- 0.6 pmol/l and 5.1 +/- 0.7, P < 0.05. The Na+K+-ATPase activity increased significantly (2,769 +/- 169 mu mol P/l erythrocyte per hour vs. 2,156 +/- 110 in the control pe riod, P < 0.01) and the Na+/Li+ countertransport decreased (268 +/- 28 mu mol Li/l erythrocyte per hour vs. 328 + 26 in the control period, P < 0.03). The bone mineral density Z score rose from -1.3 +/- 0.26 to -0.8 +/- 0.22 (P < 0.03). We conclude that IHU is accompanied byabnormalities of erythrocyte Na+/K+-ATPase and Na+/Li+ countertransport which are corrected by chronic hydrochlorothiazide administration. These changes could model alterations in renal tubular transport mechanisms still to be elucidated. Chronic thiazide treatment also has a positive effect on bone mineral density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 18:35:40