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Titolo:
MAGNETIC-RESONANCE-IMAGING OF ESOPHAGEAL SQUAMOUS-CELL CARCINOMA USING MAGNETITE PARTICLES COATED WITH ANTIEPIDERMAL GROWTH-FACTOR RECEPTORANTIBODY
Autore:
SUWA T; OZAWA S; UEDA M; ANDO N; KITAJIMA M;
Indirizzi:
KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN
Titolo Testata:
International journal of cancer
fascicolo: 4, volume: 75, anno: 1998,
pagine: 626 - 634
SICI:
0020-7136(1998)75:4<626:MOESCU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; MONOCLONAL-ANTIBODY; CONTRAST AGENTS; EGF RECEPTOR; NANOPARTICLES; BRAIN; MRI; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Suwa et al., "MAGNETIC-RESONANCE-IMAGING OF ESOPHAGEAL SQUAMOUS-CELL CARCINOMA USING MAGNETITE PARTICLES COATED WITH ANTIEPIDERMAL GROWTH-FACTOR RECEPTORANTIBODY", International journal of cancer, 75(4), 1998, pp. 626-634

Abstract

A highly specific and effective magnetic resonance imaging (MRI) contrast agent was prepared by coating superparamagnetite particles with monoclonal antibodies (MAbs) directed against epidermal growth factor receptors (EGFRs), which are over-expressed in esophageal squamous cellcarcinoma. The preparation maintained both the immunoreactivity of the MAbs and the full relaxing capability of the magnetite particles. The particles of this EGFR-specific contrast agent are 13.2 +/- 1.9 nm in size, and thus, it is assumed that they ave smaller than capillary pores and, hence, able to escape scavenging by reticulo-endothelial system cells. The EGFR-specific T2-relaxing ability of this contrast agent was ascertained first in vitro, using the EGFR-expressing cell line TE8 and the EGFR-deficient cell line H69. The results in athymic vats bearing TE8 or H69 tumors revealed that the agent has EGFR-specific MRI contrast capacity in vivo. The electron-microscopic findings in TE8 tumor-bearing rats revealed that the magnetite particles had been taken up by their lysosomes. In conclusion, immune-specific MRI using magnetite particles coated with MAbs against EGFR appears to be useful in the diagnosis of squamous cell carcinoma of the esophagus. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:19:09