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Titolo: INVOLVEMENT OF BOTH L-TYPE AND N-TYPE VOLTAGE-DEPENDENT CA2-EVOKED AND VERATRIDINE-EVOKED TRANSMITTER RELEASE FROM NONADRENERGIC, NONCHOLINERGIC NERVES IN THE RABBIT IRIS SPHINCTER MUSCLE( CHANNELS IN KCL)
Autore: KAGEYAMA M; FUJITA H; NAKATA K; SHIRASAWA E;
- Indirizzi:
- SANTEN PHARMACEUT CO LTD,OPHTHALM RES DIV,8916-16 TAKAYAMA CHO IKOMA 63001 JAPAN
- Titolo Testata:
- Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 5,
volume: 355,
anno: 1997,
pagine: 638 - 644
- SICI:
- 0028-1298(1997)355:5<638:IOBLAN>2.0.ZU;2-6
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- SUBSTANCE-P ANTAGONIST; GENE-RELATED PEPTIDE; CALCIUM CHANNELS; SMOOTH-MUSCLE; NITRIC-OXIDE; GUINEA-PIG; TRIGEMINAL NERVE; CA-2+ CHANNELS; NEURONS; NEUROTRANSMISSION;
- Keywords:
- VOLTAGE-DEPENDENT CA2+ CHANNELS; OMEGA-AGATOXIN IVA; OMEGA-CONOTOXIN GVIA; NICARDIPINE; NEUROTRANSMITTER RELEASE; TACHYKININERGIC NERVES; SMOOTH MUSCLE CONTRACTIONS; RABBIT IRIS SPHINCTER MUSCLE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 36
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- M. Kageyama et al., "INVOLVEMENT OF BOTH L-TYPE AND N-TYPE VOLTAGE-DEPENDENT CA2-EVOKED AND VERATRIDINE-EVOKED TRANSMITTER RELEASE FROM NONADRENERGIC, NONCHOLINERGIC NERVES IN THE RABBIT IRIS SPHINCTER MUSCLE( CHANNELS IN KCL)", Naunyn-Schmiedeberg's archives of pharmacology, 355(5), 1997, pp. 638-644
Abstract
To determine which types of voltage-dependent Ca2+ channels mediate tachykinin release in the isolated rabbit iris sphincter muscle, we examined the effects of several Ca2+ channel modulators on contractions induced by either an elevation of the extracellular KCl concentration or application of the Na+ channel activator veratridine. Contractions caused by either 45.9 mM KCl or veratridine (10 mu M) were inhibited byspantide (10 mu M), a tachykinin receptor antagonist, and capsaicin (10 mu M), a tachykinin-depleting agent, but were not changed by atropine. Nicardipine, an L-type Ca2+ channel blocker, inhibited contractions induced by KCl and veratridine in a concentration-dependent manner. omega-Conotoxin GVIA (1 mu M), an N-type Ca2+ channel blocker, inhibited only contractions induced by lower concentrations of KCl, both whenapplied alone and when combined with nicardipine. Bay K 8644, an L-type Ca2+ channel activator, caused a spantide- and nicardipine-sensitive contraction in muscles partially depolarized with 15.9 mM KCl, and enhanced contractions induced by 15.9 mM KCl and veratridine (2 mu M) omega-Agatoxin TVA (0.3 mu M), a P-type voltage-dependent Ca2+ channel blocker, did not affect contractions induced by either KCl or veratridine. Contractions induced by exogenous substance P were not modified by any of the Ca2+ channel blockers or by Bay K 8644. These results suggest that, in the rabbit iris sphincter muscle, L- and N-type voltage-dependent Ca2+ channels are involved in neurotransmitter release from tachykininergic nerves elicited by high KCl and by veratridine.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:49:15