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Titolo:
PLASMA GABA IN CHILDREN AND ADOLESCENTS WITH MOOD, BEHAVIOR, AND COMORBID MOOD AND BEHAVIOR DISORDERS - A PRELIMINARY-STUDY
Autore:
PROSSER J; HUGHES CW; SHEIKHA S; KOWATCH RA; KRAMER GL; ROSENBARGER N; TRENT J; PETTY F;
Indirizzi:
TERRELL STATE HOSP,DEPT PSYCHOL,POB 70 TERRELL TX 75160 TERRELL STATE HOSP,DEPT PSYCHOL TERRELL TX 75160 UNIV TEXAS,SW MED CTR,DEPT PSYCHOL DALLAS TX 75230 UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 75230 VET AFFAIRS MED CTR DALLAS TX 00000
Titolo Testata:
Journal of child and adolescent psychopharmacology
fascicolo: 3, volume: 7, anno: 1997,
pagine: 181 - 199
SICI:
1044-5463(1997)7:3<181:PGICAA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; DEFICIT HYPERACTIVITY DISORDER; RECEPTOR-MEDIATED INHIBITION; H-3 IMIPRAMINE BINDING; LEARNED HELPLESSNESS; CEREBROSPINAL-FLUID; MAJOR DEPRESSION; FRONTAL-CORTEX; RAT-BRAIN; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
J. Prosser et al., "PLASMA GABA IN CHILDREN AND ADOLESCENTS WITH MOOD, BEHAVIOR, AND COMORBID MOOD AND BEHAVIOR DISORDERS - A PRELIMINARY-STUDY", Journal of child and adolescent psychopharmacology, 7(3), 1997, pp. 181-199

Abstract

Plasma GABA concentrations (pGABA) were measured in 115 inpatients (aged 7-17) with child psychiatric disorders. Group mean pGABAs were compared for 38 patients with mood disorders only (MOOD), 29 with behavior disorders only (BEH), 48 with comorbid mood and behavior disorders (MOOD + BEH), and 14 normal controls (CON, aged 14-17). The BEH group was characterized by (a) high mean pGABAs (157 vs. 133 pmol/ml), (b) lower mean pGABAs in BEH subjects who had been receiving pharmacotherapywith SSRIs or other medications (p < 0.026), and (c) decreased pGABA with increasing age (p = 0.019). These features were not found in controls or in groups of patients with mood disorders (MOOD or MOOD + BEH). Elevated mean pGABA in the BEH group appeared specifically in patients with comorbid CD and ADHD, not in patients with ADHD or CD alone (p= 0.004). No patient in BEH (or CON) had pGABA below 100 pmol/ml, butlow pGABAs were found in 15% of MOOD patients (who had no behavior disorder) and in 16% of MOOD + BEH patients. Pharmacotherapy did not change pGABAs in the MOOD or the MOOD + BEH groups. No pGABA differences were found among the anxiety disorders, either alone or with mood or behavior comorbidity. The finding that plasma GABA levels are elevated in nonmedicated behavior disorders that present in the absence of mooddisorders, and appear to lower following medication treatments, merits increased attention to the pharmacological study of nonaffective behavior disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:11:23