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Titolo:
THE DISINTEGRIN ERISTOSTATIN INTERFERES WITH INTEGRIN ALPHA-4-BETA-1 FUNCTION AND WITH EXPERIMENTAL METASTASIS OF HUMAN-MELANOMA CELLS
Autore:
DANEN EHJ; MARCINKIEWICZ C; CORNELISSEN IMHA; VANKRAATS AA; PACHTER JA; RUITER DJ; NIEWIAROWSKI S; VANMUIJEN GNP;
Indirizzi:
NIDR,CDBRB,NIH,BLDG 30,ROOM 408 BETHESDA MD 20892 UNIV NIJMEGEN HOSP,DEPT PATHOL NIJMEGEN NETHERLANDS TEMPLE UNIV,SCH MED,DEPT PHYSIOL PHILADELPHIA PA 19122 TEMPLE UNIV,SCH MED,SOL SHERRY THROMBOSIS CTR PHILADELPHIA PA 19122 SCHERING PLOUGH CORP,RES INST,DEPT TUMOR BIOL KENILWORTH NJ 07033
Titolo Testata:
Experimental cell research
fascicolo: 1, volume: 238, anno: 1998,
pagine: 188 - 196
SICI:
0014-4827(1998)238:1<188:TDEIWI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BINDING-SITE; FIBRONECTIN-RECEPTOR; VITRONECTIN-RECEPTOR; TUMOR PROGRESSION; NUDE-MICE; ALPHA-V-BETA-3 INTEGRINS; MONOCLONAL-ANTIBODY; MALIGNANT-MELANOMA; ENDOTHELIAL-CELLS; RGD LOOP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
E.H.J. Danen et al., "THE DISINTEGRIN ERISTOSTATIN INTERFERES WITH INTEGRIN ALPHA-4-BETA-1 FUNCTION AND WITH EXPERIMENTAL METASTASIS OF HUMAN-MELANOMA CELLS", Experimental cell research, 238(1), 1998, pp. 188-196

Abstract

Peptides containing the integrin recognition sequence, RGD, call inhibit experimental metastasis of mouse melanoma cells, but the. integrin(s) affected in these experiments is unknown, Besides ''classical'' RGD-binding integrins such as alpha 5 beta 1 and alpha v beta 3, RGD hasbeen reported to bind alpha 4 beta 1, and mAbs to alpha 4 beta 1 can inhibit melanoma metastasis, We investigated the mode of action of thedisintegrin eristostatin, an RGD-containing peptide isolated from snake venom, in a human melanoma experimental metastasis model, Lung colonization following i.v. injection of MV3 cells in nude mice was strongly inhibited by eristostatin. MV3 cells bound FITC-eristostatin and adhered to aristostatin-coated wells, This adhesion was partially inhibited by a GRGDSP peptide and by alpha 4 mAb. finding of FITC-eristostatin to Jurkat cells and adhesion of Jurkat (but not K562) cells to eristostatin-coated wells further suggested that eristostatin binds alpha 4 beta 1, even though, again, alpha 4 mAb only partially inhibited adhesion, Expression of alpha 4 beta 1 was enhanced in metastatic melanoma cells compared to normal melanocytes and nonmetastatic melanoma cells, Finally, eristostatin inhibited adhesion of both MV3 and CHO alpha 4 cells to the alpha 4 beta 1-ligand VCAM-1, while adhesion to other ligands via other integrins was not affected, These findings demonstrate that inhibition of melanoma cell metastasis by RGD-containing peptides such as eristostatin, may be due to interference with alpha 4 beta 1-VCAM binding, in addition to inhibition of the classical RGD-bindingintegrins. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:58:35