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Titolo:
INVOLVEMENT OF THE CYTOSKELETON IN LOCALIZATION OF PARACENTROTUS-LIVIDUS MATERNAL BEP MESSENGER-RNAS AND PROTEINS
Autore:
ROMANCINO DP; MONTANA G; DICARLO M;
Indirizzi:
CNR,IST BIOL SUILUPPO,VIA UGO MALFA 153 I-90147 PALERMO ITALY CNR,IST BIOL SUILUPPO I-90147 PALERMO ITALY
Titolo Testata:
Experimental cell research
fascicolo: 1, volume: 238, anno: 1998,
pagine: 101 - 109
SICI:
0014-4827(1998)238:1<101:IOTCIL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LOCALIZATION; XENOPUS-OOCYTES; SPATIAL-DISTRIBUTION; DROSOPHILA EMBRYO; VEGETAL CORTEX; MICROTUBULES; EGGS; POLARITY; PATTERN; TRANSLOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Romancino et al., "INVOLVEMENT OF THE CYTOSKELETON IN LOCALIZATION OF PARACENTROTUS-LIVIDUS MATERNAL BEP MESSENGER-RNAS AND PROTEINS", Experimental cell research, 238(1), 1998, pp. 101-109

Abstract

The maternal bep1 and bep4 mRNAs and their protein products are localized at the animal pole of Paracentrotus lividus eggs. We have examined the role of the cytoskeleton in localization both of bep RNAs and BEP proteins in unfertilized and fertilized eggs and in determining the polarity of P. lividus eggs. The use of drugs such as colchicine and cytochalasin B, which depolymerize microtubules and microfilaments respectively, revealed a perturbation of localization of bep1 and bep4 mRNAs. In contrast, the microfilament inhibitor cytochalasin B had no effect on localization of BEP1 and BEP4 antigens localization, which appears to be due only to microtubules. Moreover, the presence of bep mRNAs and BEP proteins in a microtubule preparation has been demonstrated. Maintenance of the asymmetric distribution of BEP proteins during cellular division of eggs and embryos, by association with mitotic spindle, is also shown. (C) 1998 Academic Press.

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Documento generato il 01/10/20 alle ore 07:33:25