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Titolo:
OVEREXPRESSION OF PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-GAMMA IN NIH 3T3 CELLS PROMOTES TRANSFORMATION AND TUMORIGENICITY
Autore:
SMITH MR; COURT DW; KIM HK; PARK JB; RHEE SG; RHIM JS; KUNG HF;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,LAB BIOCHEM PHYSIOL,SAIC FREDERICK FREDERICK MD 21702 NHLBI,BIOCHEM LAB,NIH BETHESDA MD 20892 NCI,FREDERICK CANC RES & DEV CTR,DIV BASIC SCI,LAB BIOCHEM PHYSIOL FREDERICK MD 21702
Titolo Testata:
Carcinogenesis
fascicolo: 1, volume: 19, anno: 1998,
pagine: 177 - 185
SICI:
0143-3334(1998)19:1<177:OOPPCI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; PROTEIN-KINASE; DNA-SYNTHESIS; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION; MITOGENIC SIGNAL; FISSION YEAST; CYCLE CONTROL; RAS; C-GAMMA-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Smith et al., "OVEREXPRESSION OF PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-GAMMA IN NIH 3T3 CELLS PROMOTES TRANSFORMATION AND TUMORIGENICITY", Carcinogenesis, 19(1), 1998, pp. 177-185

Abstract

Phosphoinositide-specific phospholipase C gamma (PLC gamma) is a key regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain of certain activated receptors and catalyses the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P-2] forming IP3 and diacylglycerol (DAG) in response to several mitogenic factors, Previously, me determined that microinjected PLC gamma inducesDNA synthesis in G(0)-arrested NIH 3T3 cells, suggesting the possibility that PLC gamma mag have an oncogenic potential, In this report, wedemonstrate that overexpression of PLC gamma in NIH 3T3 cells resultsin altered growth properties and cellular transformation, The PLC gamma/3T3 transfectants do not require serum growth factors to proliferate, display anchorage-independent growth in soft agar and induce tumorswhen transplanted into nude mice. These findings suggest that overexpression of PLC gamma facilitates the transformation of NIH 3T3 cells. Furthermore, PLC gamma expression and activity have been shown to be elevated in many human tumors, Thus, PLC gamma signaling may contributeto the promotion and/or progression of human cancers.

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Documento generato il 22/01/20 alle ore 13:28:55