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Titolo:
THE NUCLEAR EICOSANOID RECEPTOR, PPAR-GAMMA, IS ABERRANTLY EXPRESSED IN COLONIC CANCERS
Autore:
DUBOIS RN; GUPTA R; BROCKMAN J; REDDY BS; KRAKOW SL; LAZAR MA;
Indirizzi:
UNIV PENN,SCH MED,DEPT MED PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT GENET PHILADELPHIA PA 19104 AMER HLTH FDN VALHALLA NY 10595 VANDERBILT UNIV,MED CTR,DEPT CELL BIOL NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,DEPT MED NASHVILLE TN 37232
Titolo Testata:
Carcinogenesis
fascicolo: 1, volume: 19, anno: 1998,
pagine: 49 - 53
SICI:
0143-3334(1998)19:1<49:TNERPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; NONSTEROIDAL ANTIINFLAMMATORY DRUG; INTESTINAL EPITHELIAL-CELLS; PROSTAGLANDIN-H SYNTHASE-2; COLORECTAL-CANCER; ASPIRIN USE; ADIPOCYTE DIFFERENTIATION; CYCLOOXYGENASE-2 LEVELS; RECTAL ADENOMAS; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Dubois et al., "THE NUCLEAR EICOSANOID RECEPTOR, PPAR-GAMMA, IS ABERRANTLY EXPRESSED IN COLONIC CANCERS", Carcinogenesis, 19(1), 1998, pp. 49-53

Abstract

Continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) lowers the relative risk of colorectal cancer in humans and decreases tumoryield in rodents treated with carcinogens, One well documented targetfor NSAIDs is prostaglandin endoperoxide synthase (cyclooxygenase) and two isoforms of this enzyme have been identified, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), COX enzymes produce eicosanoid products, some of which have recently been shown to activate transcription mediated by the nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR gamma), whose expression is largely restricted to adipose tissue, The present study was undertaken to determineif PPAR gamma was expressed in colonic tumors, PPAR gamma messenger RNA (mRNA) and protein levels were assayed in colonic tumors and normaladjacent mucosa, as well as in a variety of human colon cancer cell lines, There was a marked increase in PPAR gamma RNA levels in four outof four of the colonic tumors compared to paired normal mucosa, wherelittle expression of PPAR gamma was detected, Western blotting analysis showed that PPAR gamma protein was expressed in four out of five colonic tumor samples, PPAR gamma was also expressed in a subset of polyps, and in certain human colon cancer cell lines as well, Additionally, we mere able to demonstrate that an eicosanoid, 15 deoxy-Delta 12,14PGJ(2), transactivated transcription of a PPRE-driven promoter in CaCo-2 cells, Thus, me have shown that PPAR gamma gene and protein expression is elevated in rodent colon tumors, in selected human colon cancer cell lines and that the PPAR gamma receptor is functional in CaCo-2 cells, Since PPAR gamma is a ligand-modulated transcription factor, itmay provide a novel target for chemopreventive strategies for colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:16:44