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Titolo:
EFFECTS OF NOMEGESTROL ACETATE ON SPONTANEOUS AND SULPROSTONE-INDUCEDUTERINE CONTRACTIONS IN PREGNANT CYNOMOLGUS MONKEYS MONITORED BY TELEMETRY
Autore:
CARBONNE B; CABROL D; CLERGET MS; GERMAIN G;
Indirizzi:
INRA,LAB NEUROBIOL FONCT VEG F-78352 JOUY EN JOSAS FRANCE INRA,LAB NEUROBIOL FONCT VEG F-78352 JOUY EN JOSAS FRANCE UNIV PARIS 06,HOP ST ANTOINE,DEPT OBSTET & GYNECOL F-75252 PARIS 05 FRANCE UNIV PARIS 05 F-75270 PARIS 06 FRANCE
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 178, anno: 1998,
parte:, 1
pagine: 150 - 155
SICI:
0002-9378(1998)178:1<150:EONAOS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIFEPRISTONE RU-486; PROGESTERONE; LABOR; PARTURITION; RECEPTORS; INDUCTION; CALCIUM; RHYTHMS; UTERUS;
Keywords:
UTERINE CONTRACTION; PROGESTERONE; PROSTAGLANDIN; CYNOMOLGUS MONKEY; TELEMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B. Carbonne et al., "EFFECTS OF NOMEGESTROL ACETATE ON SPONTANEOUS AND SULPROSTONE-INDUCEDUTERINE CONTRACTIONS IN PREGNANT CYNOMOLGUS MONKEYS MONITORED BY TELEMETRY", American journal of obstetrics and gynecology, 178(1), 1998, pp. 150-155

Abstract

OBJECTIVE: Our purpose was to study the effects of the progestomimetic compound nomegestrol acetate on spontaneous and sulprostone-induced uterine contractility in pregnant cynomolgus monkeys. STUDY DESIGN: Intrauterine pressure was continuously monitored with use of an implanted intraamniotic catheter and a telemetric pressure transmitter from day 115 to 135 of gestation (term = 165 days). After surgery the animalsreceived either nomegestrol acetate (5 mg per day orally, n = 3) or vehicle only (controls, n = 3). The intramuscular prostaglandin E-2 analog sulprostone (25 mu g) was administered as a single injection 10 days after amniotic catheter implantation. Spontaneous and sulprostone-induced uterine contractions were compared between nomegestrol acetate-and vehicle-treated animals. RESULTS: The frequency of spontaneous uterine contractions in control animals demonstrated a 24-hour pattern with a minimum at 12 hours and a maximum at 0 hours. The frequency of spontaneous contractions did not differ between nomegestrol acetate-and vehicle-treated animals. Sulprostone induced an increase in both the frequency and amplitude of contractions, reaching a maximum 12 hours after injection and fading out after 24 hours in vehicle-treated animals. In animals receiving nomegestrol acetate, the frequency of contractions increased moderately and transiently for a total duration of 6 hours only and returned to control levels thereafter. CONCLUSION: Nomegestrol acetate significantly decreases the contractile response of the pregnant uterus induced by the prostaglandin E-2 analog sulprostone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:00:46