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Titolo:
ROLE OF PULMONARY C-FIBERS IN ADENOSINE-INDUCED RESPIRATORY INHIBITION IN ANESTHETIZED RATS
Autore:
KWONG K; HONG JL; MORTON RF; LEE LY;
Indirizzi:
UNIV KENTUCKY,CHANDLER MED CTR,DEPT PHYSIOL LEXINGTON KY 40536 UNIV KENTUCKY,CHANDLER MED CTR,DEPT PHYSIOL LEXINGTON KY 40536
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 84, anno: 1998,
pagine: 417 - 424
SICI:
8750-7587(1998)84:2<417:ROPCIA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPEUTIC USE; TACHYCARDIA; PHARMACOLOGY; MECHANISMS; RECEPTORS; CAPSAICIN; INVIVO; NERVE;
Keywords:
DYSPNEA; VAGUS NERVE; PULMONARY CHEMOREFLEX; A(1)-RECEPTOR; 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Kwong et al., "ROLE OF PULMONARY C-FIBERS IN ADENOSINE-INDUCED RESPIRATORY INHIBITION IN ANESTHETIZED RATS", Journal of applied physiology, 84(2), 1998, pp. 417-424

Abstract

The clinical use of adenosine is commonly associated with pulmonary side effects, namely dyspnea, that suggest the possible involvement of bronchopulmonary sensory afferents. Our objective in this study was tocharacterize the effects of adenosine on breathing and to determine whether the vagal pulmonary afferents play a role in mediating these effects. We measured respiratory and cardiovascular changes in anesthetized, spontaneously breathing rats after bolus injections of adenosine at therapeutic doses. Right atrial injection of adenosine (0.04-0.6 mg/kg) elicits, in a dose-dependent manner, a pulmonary chemoreflex-likeresponse consisting of a delayed apnea, bradycardia, and hypotension. In contrast, the classic capsaicin-elicited pulmonary chemoreflex occurs immediately after injection. Perineural capsaicin treatment of thecervical vagi blocked the adenosine-induced respiratory inhibition. Left ventricular administration of adenosine failed to elicit an apneicresponse. Pretreatment with the adenosine Al-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine attenuated the adenosine-induced apnea. These results indicate that adenosine elicits a respiratory inhibition via stimulation of pulmonary C fibers and that activation of the A(1)-receptor is probably involved. It is unclear, however, what accountsfor the exceedingly long latency in this response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:27:39