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Titolo:
CLONING AND MAPPING OF CAT (FELIS-CATUS) IMMUNOGLOBULIN AND T-CELL RECEPTOR GENES
Autore:
CHO KW; YOUN HY; OKUDA M; SATOH H; CEVARIO S; OBRIEN SJ; WATARI T; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,GRAD SCH AGR & LIFE SCI,DEPT VET INTERNAL MED,BUNKYO KU,1-1-1 YAYOI TOKYO 113 JAPAN SEOUL NATL UNIV,COLL VET MED,DEPT VET INTERNAL MED SEOUL 151742 SOUTHKOREA UNIV TOKYO,INST MED SCI,DEPT PATHOL,MINATO KU TOKYO 108 JAPAN NCI,LAB GENON DIVERS FREDERICK MD 21702
Titolo Testata:
Immunogenetics
fascicolo: 3, volume: 47, anno: 1998,
pagine: 226 - 233
SICI:
0093-7711(1998)47:3<226:CAMOC(>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE NUCLEOTIDE-SEQUENCE; DELTA-CHAIN GENES; ALPHA-CHAIN; GAMMA-CHAIN; MOLECULAR-CLONING; ANTIGEN RECEPTOR; CHROMOSOMAL TRANSLOCATIONS; MOUSE IMMUNOGLOBULIN; CONSTANT REGIONS; BETA-CHAIN;
Keywords:
CAT; IG; TCR; CLONING; MAPPING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Cho et al., "CLONING AND MAPPING OF CAT (FELIS-CATUS) IMMUNOGLOBULIN AND T-CELL RECEPTOR GENES", Immunogenetics, 47(3), 1998, pp. 226-233

Abstract

Molecular cloning and chromosomal mapping of the cat immunoglobulin (Ig) and T-cell receptor (TcR) genes were carried out to provide basic information For genetic analysis of immunologic diseases including leukemias and lymphomas in cats. We cloned two ii: constant genes, IGHM and IGHG and three Ten constant genes, TRAC, TRGC, and TRDC, by polymerase chain reaction (FCR) amplification of cDNA from cat peripheral blood mononuclear cells. For chromosomal mapping of tile ip and TcR loci including the IGK, TC;I, and TRB on the cat genome, we performed PCR screening of DNAs li-om 37 cat x rodent somatic cell hybrids by using specific primers for the given genes, Consequently, three loci for IGH,TRA, and TRD, and two loci for TRB and TRG were found to be syntenic and assigned to cat chromosomes (FCA) B3 and A2, respectively. Further, IGK and IGL loci were mapped on FCA A3 and D3, respectively. These findings support the notion that the genetic linkages between the Ig and TcR genes are extensively conserved between humans and cats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:01:22