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Titolo:
RETINOID-X-RECEPTOR GAMMA-GENE TRANSCRIPTS ARE EXPRESSED BY A SUBSET OF EARLY GENERATED RETINAL CELLS AND EVENTUALLY RESTRICTED TO PHOTORECEPTORS
Autore:
HOOVER F; SELEIRO EAP; KIELLAND A; BRICKELL PM; GLOVER JC;
Indirizzi:
UNIV OSLO,DEPT ANAT,POB 1105 N-0317 OSLO NORWAY UNIV OSLO,DEPT ANAT N-0317 OSLO NORWAY INST CHILD HLTH,MOL HAEMATOL UNIT LONDON WC1N 1EH ENGLAND
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 391, anno: 1998,
pagine: 204 - 213
SICI:
0021-9967(1998)391:2<204:RGTAEB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CHICK RETINA; IN-VITRO; ALDEHYDE DEHYDROGENASE; NEURAL RETINA; AUTORADIOGRAPHIC ANALYSIS; VERTEBRATE RETINA; GANGLION-CELLS; ACID; DIFFERENTIATION; PATTERNS;
Keywords:
9-CIS RETINOIC ACID; DEVELOPMENT; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
F. Hoover et al., "RETINOID-X-RECEPTOR GAMMA-GENE TRANSCRIPTS ARE EXPRESSED BY A SUBSET OF EARLY GENERATED RETINAL CELLS AND EVENTUALLY RESTRICTED TO PHOTORECEPTORS", Journal of comparative neurology, 391(2), 1998, pp. 204-213

Abstract

We have examined the distribution of the retinoid X receptor gamma (RXR gamma) in the developing chicken retina by using in situ hybridization and RNase protection assays. We detected RXR gamma transcripts as early as 4 days of embryonic development (d4) in central regions of the retina, spreading to more peripheral regions by d8. The first few RXR gamma-positive cells were scattered within the depth of the retinal neuroepithelium, but as they increased in number they became localizedpredominantly to the apical (outer, ventricular) layer. The identity of the RXR gamma-positive cells at these stages is unknown, due to thelack of cell type-specific markers. By d10, when photoreceptors and ganglion cells have been generated and begun to establish their definitive layers, RXR gamma-positive cells were virtually restricted to the photoreceptor layer, and maintained this distribution to posthatch stages. RNase protection assays were performed on whole retinae to verifythe temporal pattern of in situ hybridization results and showed thatbetween d5 and d16 there was a significant increase in the mRNA levels of the RXR gamma 2 isoform. Between d16 and early posthatch stages the level of RXR gamma 2 mRNA did not change significantly. Consistent with previous studies, mRNA levels of the RXR gamma 1 isoform were substantially lower than mRNA levels of the RXR gamma 2 isoform at all time points examined. These results demonstrate that RXR gamma mRNA is expressed in photoreceptors in the developing chicken retina and implicate RXR gamma as the earliest marker of photoreceptor differentiation documented to date. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 07/07/20 alle ore 12:18:46