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Titolo:
OXIDATIVE STRESS AND DEGENERATIVE TEMPOROMANDIBULAR-JOINT DISEASE - APROPOSED HYPOTHESIS
Autore:
MILAM SB; ZARDENETA G; SCHMITZ JP;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT ORAL & MAXILLOFACIAL SURG,7703 FLOYD CURL DR SAN ANTONIO TX 78284
Titolo Testata:
Journal of oral and maxillofacial surgery
fascicolo: 2, volume: 56, anno: 1998,
pagine: 214 - 223
SICI:
0278-2391(1998)56:2<214:OSADTD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CHRONIC GRANULOMATOUS-DISEASE; NF-KAPPA-B; ARACHIDONIC-ACID METABOLISM; NITRIC-OXIDE SYNTHASE; SYNOVIAL-FLUID; FREE-RADICALS; LIPID-PEROXIDATION; FIBRONECTIN FRAGMENTS; FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
99
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Milam et al., "OXIDATIVE STRESS AND DEGENERATIVE TEMPOROMANDIBULAR-JOINT DISEASE - APROPOSED HYPOTHESIS", Journal of oral and maxillofacial surgery, 56(2), 1998, pp. 214-223

Abstract

The molecular events that underlie degenerative temporomandibular joint diseases are poorly understood. Recent studies have provided evidence that a variety of molecular species, including cytokines, matrix degrading enzymes, neuropeptides, and arachidonic acid catabolites may be involved, This paper advances the theory that mechanical stresses lead to the accumulation of damaging free radicals in affected articulartissues of susceptible individuals. This condition is called oxidative stress. The authors postulate mechanisms that may be involved in theproduction of free radicals in the temporomandibular joint and in thesubsequent induction of molecular events that may amplify damage of articular tissues initiated by free radicals. Lf the proposed model is correct, then future therapeutic strategies directed at the control ofoxidative stress could be effective in the management of degenerativetemporomandibular joint diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:41:05