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Titolo:
2 PIMARANE DITERPENOIDS FROM EPHEMERANTHA-LONCHOPHYLLA AND THEIR EVALUATION AS MODULATORS OF THE MULTIDRUG-RESISTANCE PHENOTYPE
Autore:
MA GX; WANG TS; YIN L; PAN Y; GUO YL; LEBLANC GA; REINECKE MG; WATSON WH; KRAWIEC M;
Indirizzi:
TEXAS CHRISTIAN UNIV,DEPT CHEM,BOX 298860 FT WORTH TX 76129 NANJING UNIV TRADIT CHINESE MED,INST TRADIT CHINESE MED & PHARMACOL NANJING 210029 PEOPLES R CHINA CHINA PHARMACEUT UNIV,DIV ANALYT CHEM NANJING 210009 PEOPLES R CHINA N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695
Titolo Testata:
Journal of natural products
fascicolo: 1, volume: 61, anno: 1998,
pagine: 112 - 115
SICI:
0163-3864(1998)61:1<112:2PDFEA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G.X. Ma et al., "2 PIMARANE DITERPENOIDS FROM EPHEMERANTHA-LONCHOPHYLLA AND THEIR EVALUATION AS MODULATORS OF THE MULTIDRUG-RESISTANCE PHENOTYPE", Journal of natural products, 61(1), 1998, pp. 112-115

Abstract

Two new pimarane diterpenoids, lonchophylloids A(1) and B (2), were isolated from the stems of Ephemerantha lonchophylla. The structures of1 and 2 were established predominantly through the application of extensive H-1-and C-13-NMR, 1D-and 2D-homonuclear and heteronuclear correlation NMR experiments, and X-ray diffraction methods. Consistent withstructure-activity predictions, both compounds were capable of sensitizing cells that expressed the multidrug resistance phenotype to the toxicity of the anticancer drug doxorubicin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 01:44:01