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Titolo:
THE ROLE OF STRIATAL DOPAMINERGIC MECHANISMS IN ROTATIONAL BEHAVIOR INDUCED BY PHENCYCLIDINE AND PHENCYCLIDINE-LIKE DRUGS
Autore:
MELE A; WOZNIAK KM; HALL FS; PERT A;
Indirizzi:
NIMH,BIOL PSYCHIAT BRANCH,NIH BETHESDA MD 20892 NIMH,BIOL PSYCHIAT BRANCH,NIH BETHESDA MD 20892 NIAAA,CLIN STUDIES LAB BETHESDA MD 20892
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 135, anno: 1998,
pagine: 107 - 118
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTIC ACID; NMDA RECEPTOR ANTAGONIST; RAT PREFRONTAL CORTEX; GUINEA-PIG BRAIN; INCREASES EXTRACELLULAR DOPAMINE; INDUCED LOCOMOTOR-ACTIVITY; MONOAMINE-DEPLETED MICE; AFFINITY BINDING-SITES; NUCLEUS-ACCUMBENS; INVIVO MICRODIALYSIS;
Keywords:
PHENCYCLIDINE; ROTATIONAL BEHAVIOR; STRIATAL DOPAMINE; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
110
Recensione:
Indirizzi per estratti:
Citazione:
A. Mele et al., "THE ROLE OF STRIATAL DOPAMINERGIC MECHANISMS IN ROTATIONAL BEHAVIOR INDUCED BY PHENCYCLIDINE AND PHENCYCLIDINE-LIKE DRUGS", Psychopharmacology, 135(2), 1998, pp. 107-118

Abstract

Phencyclidine (PCP) and phencyclidine-like drugs (TCP, dexoxadrol, MK-801, and SKF 10,047) were evaluated for their ability to induce rotational behavior in rats with unilateral 6-OHDA lesions of the medial forebrain bundle and for their ability to alter striatal dopamine (DA) overflow with microdialysis procedures. All of the compounds tested produced rotational behavior ipsilateral to the lesion, suggesting that they were enhancing extracellular dopamine in the intact striatum. The microdialysis studies, however, did not support this contention. Thereappeared to be a complete dissociation between the ability of the five compounds to produce ipsilateral rotations and their ability to enhance extracellular dopamine levels in the striatum. PCP was the only compound able to elicit significant increases in striatal dopamine overflow following IP injections and also produce dramatic rotational behavior. MK-801 was the most potent compound in enhancing rotational output while it had no effect at all on striatal dopamine overflow. Dexoxadrol also produced significant rotational output without having any effect on extracellular levels of dopamine following IP injections. TCP and SKF 10,047, at doses which produced significant rotational behavior, only elevated dopamine 16% and 12%, respectively, at peak effect. Itis most parsimonious to conclude that the effects of PCP-like drugs on nigro-striatal function are mediated through their ability to act asindirect NMDA receptor antagonists and not through their ability to alter striatal dopamine activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:33:17