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Titolo:
EARLY MORPHOLOGICAL FINDINGS IN EXPERIMENTAL HIGH-PRESSURE NEUROLOGICAL SYNDROME
Autore:
MENNEL HD; STUMM G; WENZEL J;
Indirizzi:
UNIV KLIN,ABT NEUROPATHOL D-35033 MARBURG GERMANY UNIV MARBURG,DEPT NEUROPATHOL MARBURG GERMANY DLR,INST LUFT RAUMFAHRTMED COLOGNE GERMANY
Titolo Testata:
Experimental and toxicologic pathology
fascicolo: 6, volume: 49, anno: 1997,
pagine: 425 - 432
SICI:
0940-2993(1997)49:6<425:EMFIEH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS;
Keywords:
HPNS (HIGH PRESSURE NEUROLOGICAL SYNDROME); TISSUE PRESERVATION IN PRESSURE EXPERIMENTS; DARK NEURONS; ANIMAL MODEL FOR PSYCHOSIS; HIGH PRESSURE NEUROLOGICAL SYNDROME (HPNS); NEURONS, DARK; PSYCHOSIS, ANIMAL MODEL; PRESSURE EXPERIMENTS, TISSUE PRESERVATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H.D. Mennel et al., "EARLY MORPHOLOGICAL FINDINGS IN EXPERIMENTAL HIGH-PRESSURE NEUROLOGICAL SYNDROME", Experimental and toxicologic pathology, 49(6), 1997, pp. 425-432

Abstract

HPNS (high pressure neurological syndrome) is considered to be reversible condition of the nervous system caused by elevated (atmospheric) pressure. Clinical observations and experimental findings gave rise tothe belief that this syndrome at least partly functions as a model ofa dopamin dependent psychosis. Morphological alterations during or after HPNS in man and animals have not been reported so far. We treated rats for three hours with an increasing pressure of helium-oxygen mixture up to 61 ATA in a pressure chamber. This pressure was subsequentlymaintained for one hour and then released to zero within twenty seconds. The rats died within the first three seconds of pressure release due to complete deoxygenation. Brains were immediately removed and either cooled in liquid nitrogen or fixed in formalin. In both instances the central nervous tissue was excellently preserved. In paraffin embedded formalin fixed specimens, dark neurons in different brain regions were found, especially within parts of the dentate gyrus, the CA 4 subfield of the ammons horn, in dopaminergic brainstem nuclei and in somecortical pyramidal cells. In dopaminergic cells, tyrosine hydroxylasewas found to be absent in cells transformed into dark neurons. These dark neurons which have long been recognized in neuropathology, probably represent reversibly damaged neurons transformed into the dark configuration by aldehyde fixation. They may correspond to early apoptosisor they may be the consequence of cytoskeletal disruption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:56:42