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Titolo:
RANDOMIZED PLACEBO-CONTROLLED CROSSOVER TRIAL ON EFFECT OF INACTIVATED INFLUENZA VACCINE ON PULMONARY-FUNCTION IN ASTHMA
Autore:
NICHOLSON KG; NGUYENVANTAM JS; AHMED AH; WISELKA MJ; LEESE J; AYRES J; CAMPBELL JH; EBDEN P; EISER NM; HUTCHCROFT BJ; PEARSON JCG; WILLEY RF; WOLSTENHOLME RJ; WOODHEAD MA;
Indirizzi:
LEICESTER ROYAL INFIRM,DEPT TROP MED & INFECT DIS LEICESTER LE1 5WW LEICS ENGLAND QUEENS MED CTR,DEPT EPIDEMIOL & PUBL HLTH MED NOTTINGHAM NG7 2UH ENGLAND DEPT HLTH LONDON SE1 6TE ENGLAND BIRMINGHAM HEARTLANDS HOSP,DEPT MED RES BIRMINGHAM B9 5ST W MIDLANDS ENGLAND GRANTHAM & DIST HOSP GRANTHAM LINCS ENGLAND PRINCE PHILIP HOSP LLANELLI DYFED WALES LEWISHAM HOSP LONDON SE13 6LH ENGLAND SHEFFIELD CHEST CLIN SHEFFIELD S YORKSHIRE ENGLAND ROYAL LANCASTER INFIRMARY LANCASTER ENGLAND ROYAL ALBERT EDWARD INFIRMARY WIGAN ENGLAND MANCHESTER ROYAL INFIRM MANCHESTER M13 9WL LANCS ENGLAND
Titolo Testata:
Lancet
fascicolo: 9099, volume: 351, anno: 1998,
pagine: 326 - 331
SICI:
0140-6736(1998)351:9099<326:RPCTOE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDREN; EXACERBATIONS; ADULTS; INFECTIONS; VIRUS; PRECIPITANTS; IMMUNIZATION; REACTIVITY; COMMUNITY; SAFETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K.G. Nicholson et al., "RANDOMIZED PLACEBO-CONTROLLED CROSSOVER TRIAL ON EFFECT OF INACTIVATED INFLUENZA VACCINE ON PULMONARY-FUNCTION IN ASTHMA", Lancet, 351(9099), 1998, pp. 326-331

Abstract

Background Despite current recommendations, many people with asthma do not receive annual vaccination against influenza, partly because of concern that vaccine may trigger exacerbations. Colds can trigger exacerbations, which may be mistaken for vaccine-related adverse events. We undertook a double-blind placebo-controlled multicentre crossover study to assess the safety of influenza vaccine in patients with asthma,with allowance for the occurrence of colds. Methods We studied 262 patients, aged 18-75 years, who recorded daily peak expiratory flow (PEF), respiratory symptoms, medication, medical consultations, and hospital admissions for 2 weeks before the first injection and until 2 weeksafter the second injection. Order of injection (vaccine and placebo) was assigned randomly. There was an interval of 2 weeks between injections. The main outcome measure was an exacerbation of asthma within 72h of injection (defined as a fall in PEF of >20%). Findings Among 255participants with paired data, 11 recorded a fall in PEF of more than20% after vaccine compared with three after placebo (McNemar's test p=0.06); a fall of more than 30% was recorded by eight after vaccine compared with none after placebo (binomial test p=0.008). However, when participants with colds were excluded, there was no significant difference in the numbers with falls of more than 20% between vaccine and placebo (six vs three; binomial test p=0.51), although the difference for PEF decreases of more than 30% approached significance (five vs none; binomial test, p=0.06). This association was confined to first-time vaccinees. Interpretation Our findings indicate that pulmonary-function abnormalities may occur as a complication of influenza vaccination. However, the risk of pulmonary complications is very small and outweighted by the benefits of vaccination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:20:14