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Titolo:
LACK OF AUTONOMIC CONTRIBUTIONS TO TONIC NITRIC OXIDE-MEDIATED VASODILATATION IN UNANESTHETIZED FREE-MOVING RATS
Autore:
RADAELLI A; MIRCOLI L; PERLINI S; BOLLA G; MORI I; MANCIA G; FERRARI AU;
Indirizzi:
CTR FISIOL CLIN & IPERTENS,VIA F SFORZA 35 I-20122 MILAN ITALY OSPED SEREGNO,AZUSSL 30,DIV CARDIORIABILITAZ DESIO ITALY UNIV MILAN,OSPED MAGGIORE,CATTEDRA CARDIOANGIOL MED,CTR FISIOL CLIN &IPERTENS MILAN ITALY CNR I-20133 MILAN ITALY
Titolo Testata:
Journal of hypertension
fascicolo: 1, volume: 16, anno: 1998,
pagine: 55 - 61
SICI:
0263-6352(1998)16:1<55:LOACTT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE METHYL-ESTER; RELAXING FACTOR; CHRONIC INHIBITION; ENDOTHELIAL-CELLS; CONSCIOUS RATS; HYPERTENSION; ACETYLCHOLINE; MODULATION; ARTERIES; RELEASE;
Keywords:
NITRIC OXIDE; L-NITROMONOMETHYL-L-ARGININE; SYMPATHECTOMY; GANGLIONIC BLOCKADE; SINOAORTIC DENERVATION; BLOOD PRESSURE; UNANESTHETIZED RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Radaelli et al., "LACK OF AUTONOMIC CONTRIBUTIONS TO TONIC NITRIC OXIDE-MEDIATED VASODILATATION IN UNANESTHETIZED FREE-MOVING RATS", Journal of hypertension, 16(1), 1998, pp. 55-61

Abstract

Objective To clarify the controversial issue of whether autonomic influences modulate vascular nitric oxide-mediated vasodilatation or evendirectly contribute to production of nitric oxide (NO) via nitroxidergic fibers. Methods Chronic venous and arterial catheters were implanted in Wistar-Kyoto rats (n = 65) for continuous blood pressure measurement, drug administration and blood sampling. Tonic NO-dependent vasodilatation in the conscious free-moving animal was evaluated as the pressor response to inhibition of NO synthesis by intravenous L-monomethylarginine (a 100 mg/kg intravenous bolus plus 0.5 mg/kg per min infusion for 30 min). Experiments were performed under control conditions, chemical sympathectomy by 6-hydroxydopamine, ganglionic blockade by hexamethonium, and surgical denervation of sino-aortic baroreceptors. Results Baseline mean arterial pressure was 100 +/- 4 mmHg (mean +/- SEM)in control rats and 73 +/- 3, 62 +/- 5, and 105 +/- 10 mmHg in sympathectomized, ganglion-blocked, and denervated rats, respectively. The peak increase in mean arterial pressure after administration of L-monomethylarginine was 38 +/- 3 mmHg in control rats and 51 +/- 3, 50 +/- 6, and 63 +/- 10 mmHg in sympathectomized, ganglion-blocked, and denervated rats, respectively. Epinephrine and norepinephrine levels in ratsof separate groups of unanesthetized control, sympathectomized and ganglion-blocked animals were measured by high-performance liquid chromatography from an arterial blood sample, the results indicating drasticreductions in levels of both catecholamines in the ganglion-blocked (but not in the sympathectomized) rats compared with those in the control rats. Conclusions Tonic NO-dependent vasodilatation can normally bemaintained in the unanesthetized unrestrained rat irrespective of autonomic or humoral adrenergic influences. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:24:04