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Titolo:
NATURAL-KILLER-CELL AS THE EFFECTOR WHICH MEDIATES IN-VIVO APOPTOSIS IN AK-5 TUMOR-CELLS
Autore:
KHAR A; PARDHASARADHI BVV; VARALAKSHMI C; ALI AM; KUMARI AL;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cellular immunology
fascicolo: 1, volume: 177, anno: 1997,
pagine: 86 - 92
SICI:
0008-8749(1997)177:1<86:NATEWM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; RAT HISTIOCYTOMA; IN-VIVO; DEATH; CYTOTOXICITY; LYMPHOCYTES; EXTRACTION; MECHANISM; CYTOLYSIS; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar et al., "NATURAL-KILLER-CELL AS THE EFFECTOR WHICH MEDIATES IN-VIVO APOPTOSIS IN AK-5 TUMOR-CELLS", Cellular immunology, 177(1), 1997, pp. 86-92

Abstract

AK-5 tumor cell death is mediated by natural killer cells through necrosis (perforin mediated) and apoptosis. Apoptosis is the mechanism which operates in immune animals in vivo. We have identified natural killer (NK) cell as the effector cell which induces apoptosis leading to tumor cell. death in vivo. Naive NK cell which is unable to kill the AK-5 tumor cell can be activated with IL-2/IL-12 to make it capable of inducing apoptosis in tumor cells. NK cells from tumor-rejected animals show higher expression of Fas ligand and serine esterase granzyme B,In addition, NK cell-mediated apoptosis in AK-5 cells is totally abolished when effector cells are treated with anti-NKR-P1 mAb 3.2.3 and complement, NK cell-mediated apoptotic activity is inhibited in bcl-2 transfected tumor cells; however, the cytotoxic activity (perforin-mediated) remains unaffected. These observations suggest an important rolefor activated NK cells in inducing tumor cell death through necrosis (ADCC) and apoptosis leading to spontaneous regression of the AK-5 tumor in syngeneic animals. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:10:40