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Titolo:
SPECIFIC PROTEOLYTIC CLEAVAGE OF THE MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE BETWEEN ASN-147 AND GLU-148 ALSO OCCURS IN BRAIN
Autore:
MANENTI S; TANIGUCHI H; SOROKINE O; VANDORSSELAER A; DARBON JM;
Indirizzi:
CHU PURPAN,CJF 95-10,PAVILLON RAYER F-31059 TOULOUSE FRANCE INSERM TOULOUSE FRANCE CNRS,LAB CHIM ORGAN SUBSTANCES NAT,URA 31 STRASBOURG FRANCE FUJITA HLTH UNIV,INST COMPREHENS MED SCI,DIV BIOPOLYMER SCI TOYOAKE AICHI JAPAN
Titolo Testata:
Journal of neuroscience research
fascicolo: 3, volume: 48, anno: 1997,
pagine: 259 - 263
SICI:
0360-4012(1997)48:3<259:SPCOTM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR SUBSTRATE; CALMODULIN-BINDING; DOWN-REGULATION; BOVINE BRAIN; 3T3 CELLS; PROTEIN; MARCKS; MEMBRANE; PHOSPHORYLATION; FIBROBLASTS;
Keywords:
PROTEIN KINASE C SUBSTRATE; NATURAL DEGRADATION; BRAIN; MASS SPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S. Manenti et al., "SPECIFIC PROTEOLYTIC CLEAVAGE OF THE MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE BETWEEN ASN-147 AND GLU-148 ALSO OCCURS IN BRAIN", Journal of neuroscience research, 48(3), 1997, pp. 259-263

Abstract

The myristoylated alanine-rich C kinase substrate (MARCKS) is a majorubiquitous substrate of protein kinase C, The expression of the protein is regulated during cell cycle progression and cell proliferation, Specific proteolytic cleavage of the protein between Asn 147 and Glu 148 was described recently in cultured cells, and the corresponding proteolytic activity was observed in various tissue extracts except for brain, We purified a 40 kDa fragment of MARCKS from bovine brain that we characterized as the C-terminal specific fragment found in other tissues, The identification of the fragment was achieved by in vitro phosphorylation by protein kinase C, calcium-dependent interaction with calmodulin, mass spectrometric analysis, and N-terminal sequencing, These data suggest that specific proteolytic cleavage of MARCKS also occurs in brain and may be a general mechanism of down-regulation of the protein. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:28:04