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Titolo:
NORMAL VARIATION IN SIZE OF THE FMR1 GENE IS NOT ASSOCIATED WITH VARIATION IN INTELLECTUAL-PERFORMANCE
Autore:
MAZZOCCO MMM; REISS AL;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,KENNEDY KRIEGER INST BALTIMORE MD 21205
Titolo Testata:
Intelligence
fascicolo: 2, volume: 24, anno: 1997,
pagine: 355 - 366
SICI:
0160-2896(1997)24:2<355:NVISOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGILE-X-SYNDROME; FULL MUTATION; CGG REPEAT; PREMUTATION; PHENOTYPE; EXPRESSION; FEMALES; IQ; INTELLIGENCE; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.M.M. Mazzocco e A.L. Reiss, "NORMAL VARIATION IN SIZE OF THE FMR1 GENE IS NOT ASSOCIATED WITH VARIATION IN INTELLECTUAL-PERFORMANCE", Intelligence, 24(2), 1997, pp. 355-366

Abstract

The fragile X mental retardation (FMR1) gene was examined as a potential single-gene candidate for variation in intelligence score, on the basis of its well established relation with mental retardation. The size of the normal FMR1 gene varies across individuals, and is measured by the number of cytosine-guanine-guanine (CGG) repeats of which it iscomprised. In this study, the association between IQ score and the number of CGG repeats was examined among 917 school age children, including 455 Caucasian children and 462 African American children. Separateanalyses were conducted with the entire sample, with girls and boys examined separately, and with Caucasian and African American subgroups. None of the models revealed a statistically significant association between IQ and number of CGG repeats. The results from this study provide strong evidence that variation in CGG size, among normal size FMR1 alleles, does not account for variation in intelligence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:00:29