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Titolo:
RUMEN-STABLE DELIVERY SYSTEMS
Autore:
WU SHW; PAPAS A;
Indirizzi:
EASTMAN CHEM CO,TECH SERV KINGSPORT TN 37663 EASTMAN CHEM CO,DEV DIV KINGSPORT TN 37663
Titolo Testata:
Advanced drug delivery reviews
fascicolo: 3, volume: 28, anno: 1997,
pagine: 323 - 334
SICI:
0169-409X(1997)28:3<323:>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTECTED METHIONINE; DAIRY-COWS; AMINO-ACIDS; SUPPLEMENTATION; RESPONSES; PROTEIN; LAMBS;
Keywords:
RUMEN STABILITY; RUMEN-PROTECTED AMINO ACIDS; FEED ADDITIVES; RUMINANT NUTRITION; RUMEN BYPASS;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
S.H.W. Wu e A. Papas, "RUMEN-STABLE DELIVERY SYSTEMS", Advanced drug delivery reviews, 28(3), 1997, pp. 323-334

Abstract

Ruminants have a distinct digestive system which serves a unique symbiotic relationship between the host animal and predominantly anaerobiclumen bacteria and protozoa. Rumen fermentation can be both beneficial by enabling utilization of cellulose and non-protein nitrogen and detrimental by reducing the nutritive value of some carbohydrates, high biological value proteins and by hydrogenating unsaturated lipids. In addition it can also result in the modification and inactivation of many pharmacologically active ingredients administered to the host animal via the oral route. The advances in ruminant nutrition and health demand a rumen-stable delivery system which can deliver the active ingredient post-ruminally while simultaneously meet efficacy, safety and cost criteria. In contrast to drug delivery systems for humans, the demand for low-cost has hindered the development of effective rumen-stabledelivery systems. Historically, heat and chemical treatment of feed components, low solubility analogues or lipid-based formulations have been used to achieve some degree of rumen-stability, and products have been developed accordingly. Recently, a polymeric pH-dependent rumen-stable delivery system has been developed and commercialized. The rationale of this delivery system is based on the pH difference between ruminal and abomasal fluids. The delivery system is composed of a basic polymer, a hydrophobic substance and a pigment material. It can be applied as a coating to solid particles via a common encapsulation method such as air-suspension coating. In the future, the delivery system could be used to deliver micronutrients and pharmaceuticals post-ruminally to ruminant animals. A further possible application of the delivery system is that it could also be combined with other controlled delivery devices/systems in order to enhance slow release or to achieve targeted delivery needs for ruminants. This paper discusses the rumen protection and the abomasal release mechanism of the polymeric coating. It also reviews other lumen stable delivery systems and methods for evaluating their in vitro and in vivo performance. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:02:40