Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
APPEARANCE OF A FAST INACTIVATING VOLTAGE-DEPENDENT K-VITRO( CURRENTSIN DEVELOPING CEREBELLAR GRANULE CELLS IN)
Autore:
WAKAZONO Y; KURAHASHI T; NAKAHIRA K; NAGATA I; TAKAYAMA C; INOUE Y; KANEKO A; IKENAKA K;
Indirizzi:
NATL INST PHYSIOL SCI,DEPT INFORMAT PHYSIOL,38 NISHIGONAKA AICHI 444 JAPAN NATL INST PHYSIOL SCI,DEPT INFORMAT PHYSIOL AICHI 444 JAPAN GRAD UNIV ADV STUDIES,DEPT PHYSIOL SCI AICHI 444 JAPAN TOKYO METROPOLITAN INST NEUROSCI,DEPT CELL BIOL TOKYO 183 JAPAN HOKKAIDO UNIV,SCH MED,DEPT ANAT,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Neuroscience research
fascicolo: 4, volume: 29, anno: 1997,
pagine: 291 - 301
SICI:
0168-0102(1997)29:4<291:AOAFIV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL INHIBITORY INTERNEURONS; AMPHIBIAN SPINAL NEURONS; EXTERNAL GERMINAL LAYER; MICROEXPLANT CULTURES; PERPENDICULAR ORIENTATION; SYMPATHETIC NEURONS; POTASSIUM CURRENT; HORIZONTAL CELLS; RAT CEREBELLUM; WHOLE-CELL;
Keywords:
CEREBELLUM; GRANULE CELL; MICROEXPLANT CULTURE; DEVELOPMENT; MORPHOLOGY; VOLTAGE-DEPENDENT K+ CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y. Wakazono et al., "APPEARANCE OF A FAST INACTIVATING VOLTAGE-DEPENDENT K-VITRO( CURRENTSIN DEVELOPING CEREBELLAR GRANULE CELLS IN)", Neuroscience research, 29(4), 1997, pp. 291-301

Abstract

To elucidate the molecular mechanisms that regulate the maturation ofaction potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in this culture is reported to mimicthe in vivo process, but their specific identification is still incomplete. In this study, we identified and characterized granule cells inthis culture. Immunocytochemical analysis found that granule cells migrated radially out from explants and subsequently formed small clusters and also that their morphology changed from a bipolar to a T shape during migration. Moreover, in the electrophysiological study, the GABA response of granule cells in this culture clarified that the electrophysiological properties of granule cells were normally maintained. Wetherefore have concluded, that this culture system is a powerful toolfor investigating the differentiation of cerebellar granule cells. Based on these findings, we recorded voltage-dependent K+ currents of developing granule cells in this culture, while concurrently observing their morphology. Our results show that voltage-dependent K+ currents of developing granule cells change from delayed rectifier to A current in parallel with their morphological changes from bipolar to T-shaped cells. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:19:12