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Titolo:
ARGYROPHILIC GRAIN DISEASE - WIDESPREAD HYPERPHOSPHORYLATION OF TAU-PROTEIN IN LIMBIC NEURONS
Autore:
TOLNAY M; SPILLANTINI MG; GOEDERT M; ULRICH J; LANGUI D; PROBST A;
Indirizzi:
UNIV BASEL,INST PATHOL,SCHONBEINSTR 40 CH-4003 BASEL SWITZERLAND MRC,MOL BIOL LAB CAMBRIDGE CB2 2QH ENGLAND
Titolo Testata:
Acta Neuropathologica
fascicolo: 5, volume: 93, anno: 1997,
pagine: 477 - 484
SICI:
0001-6322(1997)93:5<477:AGD-WH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-ONSET DEMENTIA; HELICAL-FILAMENT-TAU; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; PATHOLOGY; SER(262); SEQUENCE; ISOFORMS; BRAIN;
Keywords:
ARGYROPHILIC GRAIN DISEASE; TAU PROTEIN PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Tolnay et al., "ARGYROPHILIC GRAIN DISEASE - WIDESPREAD HYPERPHOSPHORYLATION OF TAU-PROTEIN IN LIMBIC NEURONS", Acta Neuropathologica, 93(5), 1997, pp. 477-484

Abstract

Argyrophilic grains (ArG) and coiled bodies of argyrophilic grain disease (Ago) and the neurofibrillary lesions of Alzheimer's disease (AD)share similar antigenic determinants, among them hyperphosphorylated microtubule-associated protein tau. Nothing is known about the mechanisms underlying tau hyperphosphorylation in Ago, the hyperphosphorylated sites or the intracellular distribution of abnormally phosphorylatedtau. We have analysed brain tissue sections from 41 subjects with Agowith a panel of phosphorylation-dependent (AT270, AT8, Tau-1, AT180, 12E8, PHF-1 and AT100) and phosphorylation-independent anti-tau antibodies (N-tau 5, 304, 189 and 134). All antibodies labelled ArG, coiled bodies and neurofibrillary lesions, with the exception of antibody 12E8, which stained a subset of neurofibrillary tangles, but no ArG or coiled bodies. Most pyramidal neurons in areas rich in ArG showed diffuse granular tau labelling in cell bodies and dendrites. Only very few tau-positive cells also contained neurofibrillary tangles. Phosphorylation-dependent anti-tau antibodies also stained a felt-like network of Gallyas-negative filiform neurites in layer CA1 of the hippocampus andin layer pre-B of the transentorhinal cortex. These results demonstrate a widespread hyperphosphorylation of tau protein in the somatodendritic domain of neurons in Ago, in addition to silver grains in the neuropil. Unlike in AD, tau hyperphosphorylation in the somatodendritic domain in Ago does not appear to be followed by neurofibrillary tangle formation, even in the presence of widespread ArG in the neuropil. Furthermore, our data suggest that no strict correlation exists between the presence or density of ArG in the limbic area and the occurrence ofdementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:29:35