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Titolo:
MARCKS, A MAJOR PROTEIN-KINASE-C SUBSTRATE, ASSUMES NON-HELICAL CONFORMATIONS BOTH IN SOLUTION AND IN COMPLEX WITH CA2-CALMODULIN()
Autore:
MATSUBARA M; YAMAUCHI E; HAYASHI N; TANIGUCHI H;
Indirizzi:
FUJITA HLTH UNIV,INST COMPREHENS MED SCI,DIV BIOMED POLYMER SCI AICHI47011 JAPAN FUJITA HLTH UNIV,INST COMPREHENS MED SCI,DIV BIOMED POLYMER SCI AICHI47011 JAPAN NAGOYA CITY UNIV,FAC PHARMACEUT SCI,DEPT BIOL CHEM,MIZUHO KU NAGOYA AICHI 467 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 421, anno: 1998,
pagine: 203 - 207
SICI:
0014-5793(1998)421:3<203:MAMPSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALMODULIN-BINDING DOMAIN; BOVINE BRAIN; MEMBRANE PHOSPHOLIPIDS; MOLECULAR-CLONING; PHOSPHORYLATION; ADDUCIN; FAMILY; MYRISTOYLATION; PURIFICATION; RECOGNITION;
Keywords:
MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE; PROTEIN KINASE C; CALMODULIN; PROTEIN STRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Matsubara et al., "MARCKS, A MAJOR PROTEIN-KINASE-C SUBSTRATE, ASSUMES NON-HELICAL CONFORMATIONS BOTH IN SOLUTION AND IN COMPLEX WITH CA2-CALMODULIN()", FEBS letters, 421(3), 1998, pp. 203-207

Abstract

MARCKS, a major cellular substrate for protein kinase C, plays important roles in various cellular functions and its functions are regulated by calmodulin, We have studied the conformational properties of recombinant human MARCKS in solution and in complex with calmodulin, Circular dichroism (CD) spectra showed a high content of random coil in physiological solution, When MARCKS or MARCKS-derived calmodulin-binding peptide was complexed with Ca2+-calmodulin, little change was observedin the CD spectra, suggesting that MARCKS binds with calmodulin in a non-helical conformation, which is unique among the calmodulin-bindingproteins. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:23:49