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Titolo:
THE RELATIONSHIP BETWEEN QUANTITATIVE MRI AND NEUROPSYCHOLOGICAL FUNCTIONING IN TEMPORAL-LOBE EPILEPSY
Autore:
BAXENDALE SA; VANPAESSCHEN W; THOMPSON PJ; CONNELLY A; DUNCAN JS; HARKNESS WF; SHORVON SD;
Indirizzi:
NATL HOSP NEUROL & NEUROSURG,DEPT NEUROPSYCHOL,QUEEN SQ LONDON WC1N 3BG ENGLAND INST NEUROL,EPILEPSY RES GRP LONDON WC1N 3BG ENGLAND GREAT ORMOND ST HOSP CHILDREN,MNR UNIT LONDON WC1N 3JH ENGLAND INST CHILD HLTH LONDON ENGLAND CHALFONT CTR EPILEPSY CHALFONT ST PETER BUCKS ENGLAND
Titolo Testata:
Epilepsia
fascicolo: 2, volume: 39, anno: 1998,
pagine: 158 - 166
SICI:
0013-9580(1998)39:2<158:TRBQMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERBAL MEMORY IMPAIRMENT; HIPPOCAMPAL NEURON LOSS; PATHOLOGICAL CORRELATIONS; LOBECTOMY; SURGERY; VOLUMES; PERFORMANCE; RELAXOMETRY; PREDICTION; RESECTION;
Keywords:
HIPPOCAMPAL SCLEROSIS; MEMORY; TEMPORAL LOBES; EPILEPSY; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Baxendale et al., "THE RELATIONSHIP BETWEEN QUANTITATIVE MRI AND NEUROPSYCHOLOGICAL FUNCTIONING IN TEMPORAL-LOBE EPILEPSY", Epilepsia, 39(2), 1998, pp. 158-166

Abstract

Purpose: Quantitative MRI techniques provide an unparalleled opportunity to examine in vivo the relationship between the extent and laterality of hippocampal pathology and associated neuropsychological deficits. The purpose of this study was to examine the nature of the relationship between quantitative measures of hippocampal pathology and neuropsychological measures, using a multivariate approach. Methods: We examined the relationship between two MRI measures of hippocampal structure: hippocampal volumes (HCvol) and T2 relaxation rimes (HCT2), and memory performance, in 80 presurgical temporal lobe epilepsy patients. Results: As a group, patients with left hippocampal sclerosis (LHS) performed more poorly that those with right hippocampal sclerosis (RHS) onimmediate and delayed prose recall. In the group as a whole, right hippocampal volume was significantly correlated with the delayed recall of a complex figure. None of the verbal memory test scores were significantly correlated with the right or left HCvol or HCT2 measures. However, stepwise multiple regression analyses indicated that up to a third of the variation in specific test scores could be explained by the quantitative MRI hippocampal measures in conjunction with chronologicalage, and age at onset of habitual epilepsy. Left hippocampal measuresexplained 24% of the variance in the story-recall tasks, while right hippocampal measures explained 18% of the valiance in a design-learning task and 32% of the variance in a figure-recall task. Conclusions: Our results provide some support for the lateralised model of material specific memory deficits, but suggest that a number of demographic andepilepsy-related factors may interact with the extant and laterality of hippocampal pathology in shaping the nature of the associated neuropsychological deficit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:20:43