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Titolo:
SIGNIFICANCE OF AN ECHOGENIC INTRACARDIAC FOCUS IN FETUSES AT HIGH AND LOW-RISK FOR ANEUPLOIDY
Autore:
BROMLEY B; LIEBERMAN E; SHIPP TD; RICHARDSON M; BENACERRAF BR;
Indirizzi:
DIAGNOST ULTRASOUND ASSOCIATES,333 LONGWOOD AVE BOSTON MA 02115 MASSACHUSETTS GEN HOSP,DEPT OBSTET & GYNECOL BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT RADIOL BOSTON MA 02114 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED BOSTON MA 02115
Titolo Testata:
Journal of ultrasound in medicine
fascicolo: 2, volume: 17, anno: 1998,
pagine: 127 - 131
SICI:
0278-4297(1998)17:2<127:SOAEIF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL HEART; BENIGN;
Keywords:
ECHOGENIC INTRACARDIAC FOCUS; ANEUPLOIDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
B. Bromley et al., "SIGNIFICANCE OF AN ECHOGENIC INTRACARDIAC FOCUS IN FETUSES AT HIGH AND LOW-RISK FOR ANEUPLOIDY", Journal of ultrasound in medicine, 17(2), 1998, pp. 127-131

Abstract

Our objective was to evaluate the significance of an echogenic intracardiac focus in a mixed population of fetuses at high and low risk foraneuploidy. Over a 1 year period, we prospectively identified all fetuses with an echogenic intracardiac focus seen during prenatal sonography. A detailed structural evaluation was performed on each fetus as permitted by gestational age. The location and number of foci were tabulated prospectively, as were associated abnormalities. Follow-up was obtained by review of the medical record. Of the 290 fetuses who had anechogenic intracardiac focus, 14 of them were aneuploid (4.8%). Of the 290 mothers, 125 women were aged 35 years or older and 165 women were younger than 35 years old. Among the 125 fetuses born to women 35 years or older, eight were aneuploid fetuses (6.4%), while among the 165fetuses of younger mothers, six were aneuploid fetuses (3.6%) (rate ratio = 1.8; 95% confidence interval [extremes] = 0.6, 4.9). Only one of the 14 aneuploid fetuses had an echogenic intracardiac focus as the only sonographic finding, and this occurred in a woman aged 41 years. The majority of the echogenic intracardiac foci (87.6%) were located in the left ventricle, while 4.8% of the foci were right-sided and 7.6%were bilateral. Among the 14 aneuploid fetuses, 14% had bilateral echogenic intracardiac foci and 7% had right-sided foci. Among the euploid fetuses, 7.3% had bilateral echogenic intracardiac foci and 4.7% hadright-sided foci. In conclusion, we have shown that the presence of an echogenic intracardiac focus does raise the risk that the fetus has a chromosomal abnormality, most commonly Down syndrome, although all but one aneuploid fetus in our study had other sonographic findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:10:46