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Titolo:
COGNITIVE PROCESS IN PRECLINICAL PHASE OF DEMENTIA
Autore:
FABRIGOULE C; ROUCH I; TABERLY A; LETENNEUR L; COMMENGES D; MAZAUX JM; ORGOGOZO JM; DARTIGUES JF;
Indirizzi:
UNIV BORDEAUX 2,INSERM,U330,146 RUE LEO SAIGNAT F-33076 BORDEAUX FRANCE HOP UNIV PELLEGRIN,SERV REEDUC NEUROL BORDEAUX FRANCE HOP UNIV PELLEGRIN,SERV NEUROL BORDEAUX FRANCE INST NATL SCI APPL F-31077 TOULOUSE FRANCE
Titolo Testata:
Brain
, volume: 121, anno: 1998,
parte:, 1
pagine: 135 - 141
SICI:
0006-8950(1998)121:<135:CPIPPO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; DIAGNOSIS;
Keywords:
COGNITION; DEMENTIA; PRECLINICAL SIGNS; CONTROLLED PROCESSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C. Fabrigoule et al., "COGNITIVE PROCESS IN PRECLINICAL PHASE OF DEMENTIA", Brain, 121, 1998, pp. 135-141

Abstract

Several recent prospective studies have demonstrated the existence ofa preclinical stage of dementia, identifiable by neuropsychological assessment showing impairments with a great variety of cognitive tests. However test scores are often colinear, largely because common cognitive components are involved in different tests; in spite of an apparent heterogeneity, it is still possible that a common cognitive component may be responsible for the deterioration shown in different tests inthe preclinical phase. We studied the cognitive performances of 1159 elderly residents in the PAQUID (Personnes Agees quid) cohort, at a fixed lag time of 2 years before the clinical diagnosis of dementia. Seven Status Examination, Benton Visual Retention Test, Wechsler Paired-Associates Test, Isaacs Set Test, Zazzo's Cancellation Task, Digit Symbol Substitution Test and Wechsler Similarities Test). Among the initially non-demented 1159 subjects, 25 developed a dementia 2 years Inter,of whom 16 were classified as cases of Alzheimer's disease. In order to dissect the multicolinearity of the tests we used a multivariate approach with principal component analysis (PCA). The patients' loading on each of the first four PCA factors were subsequently correlated with the risk of dementia and Alzheimer's disease 2 years later The logistic regression with backward stepwise selected only the first factor as an independent predictor of dementia or Alzheimer's disease. Analysis shows that there are good reasons to suspect that the first PCA factor represents a general factor corresponding to aspects of control in the tasks used. Our results therefore Alzheimer's disease reflect the deterioration of a general cognitive factor which may be interpreted as the disturbance of central control processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:38:42