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Titolo:
REACTIVITY TO NOVELTY IN COGNITIVELY-IMPAIRED AND COGNITIVELY-UNIMPAIRED AGED RATS AND YOUNG-RATS
Autore:
ROWE WB; SPREEKMEESTER E; MEANEY MJ; QUIRION R; ROCHFORD J;
Indirizzi:
MCGILL UNIV,DEPT PSYCHIAT,DOUGLAS HOSP,RES CTR MONTREAL PQ H3A 2T5 CANADA MCGILL UNIV,DEPT PSYCHIAT,DOUGLAS HOSP,RES CTR MONTREAL PQ H3A 2T5 CANADA
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 83, anno: 1998,
pagine: 669 - 680
SICI:
0306-4522(1998)83:3<669:RTNICA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; ACETYLCHOLINE-RELEASE; MEMORY; DRUGS; CHLORDIAZEPOXIDE; PERFORMANCE; NALOXONE; ANXIETY; STRESS; ARM;
Keywords:
AGING; NOVELTY; MEMORY; HABITUATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W.B. Rowe et al., "REACTIVITY TO NOVELTY IN COGNITIVELY-IMPAIRED AND COGNITIVELY-UNIMPAIRED AGED RATS AND YOUNG-RATS", Neuroscience, 83(3), 1998, pp. 669-680

Abstract

Two distinct populations of aged, Long-Evans rats can be identified on the basis of performance in the Morris water maze task. Aged (24 month) unimpaired rats perform similarly to young (six month) animals. Aged, impaired rats display latencies to find the submerged platform greater than two standard deviations from the mean of the young animals. A hallmark of efficient cognitive processing is the ability to cope with environmental change. Consequently, the present studies were conducted to assess if aged, impaired animals display differential reactivity to repeated exposure to novel stimuli. Reactivity was assessed by examining the degree of (i) consumption of a novel gustatory/olfactory stimulus (sweetened milk), (ii) pain inhibition induced by exposure to a novel hot-plate (48.5 degrees C) apparatus and (iii) exploratory behaviour in an elevated plus maze and a novel open field. Aged, impairedrats exhibited lower milk consumption on day one and protracted reactivity (lower consumption over days two to eight) in comparison to aged, unimpaired and young animals. Aged, impaired rats were more reactiveto novelty on the hot plate test (as indicated by longer paw lick latencies); this novelty-induced pain inhibition did not habituate in aged, impaired rats following repeated plate exposures. The degree of exploratory behaviour in both the plus maze and the open field was reduced in aged, impaired rats. This effect was not entirely a consequence of deficient affective mechanisms, as measures of anxiety (e.g., time in open arms, time in inner squares) were not different among aged impaired, aged unimpaired and young animals. These results are the first to demonstrate that behavioural deficits observed in aged, impaired animals extend beyond the impairments observed in the water maze. This behavioural profile is attributed. in part, to heightened anxiety. In addition, the impairments observed in aged, impaired animals may also reflect a reduced sensitivity to the positive incentive properties of novel stimuli. (C) 1998 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 15/07/20 alle ore 08:22:51