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Titolo:
CHIRAL DISCRIMINATION BY CHEMICAL FORCE MICROSCOPY
Autore:
MCKENDRY R; THEOCLITOU ME; RAYMENT T; ABELL C;
Indirizzi:
UNIV CAMBRIDGE,DEPT CHEM,LENSFIELD RD CAMBRIDGE CB2 1EW ENGLAND UNIV CAMBRIDGE,DEPT CHEM CAMBRIDGE CB2 1EW ENGLAND
Titolo Testata:
Nature
fascicolo: 6667, volume: 391, anno: 1998,
pagine: 566 - 568
SICI:
0028-0836(1998)391:6667<566:CDBCFM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION; FRICTION; ENANTIOMERS; CRYSTALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R. Mckendry et al., "CHIRAL DISCRIMINATION BY CHEMICAL FORCE MICROSCOPY", Nature, 391(6667), 1998, pp. 566-568

Abstract

Chirality is a fundamental aspect of chemical biology, and is of central importance in pharmacology, Consequently there is great interest in techniques for distinguishing between different chiral forms of a compound. Chemical force microscopy is a technique that combines chemical discrimination with atomic force microscopy by chemical derivatization of the scanning probe tip. It has been applied to the study of hydrophobic and hydrophilic interactions(1), the binding between biotin and streptavidin(2,3) and between DNA bases(4). Here we report on the use of chemical force microscopy to discriminate between chiral molecules. Using chiral molecules attached to the probe tip, we can distinguish the two enantiomers of mandelic acid arrayed on a surface, through differences in both the adhesion forces and the frictional forces measured by the probe.

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Documento generato il 05/12/20 alle ore 01:55:23