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Titolo:
EFFECT OF CASTRATION AND GONADAL-HORMONES ON INSULIN-INDUCED DRINKING
Autore:
FERNANDEZTRISAC JL; BRIME JI; LOPEZSELA P; SANCHEZGARRIDO L; COSTALES M; ARGUELLES J; VIJANDE M;
Indirizzi:
UNIV OVIEDO,FAC MED,DEPT BIOL FUNCT,AREA FISIOL,JULIAN CALVERIA S-N E-33006 OVIEDO SPAIN UNIV OVIEDO,FAC MED,DEPT BIOL FUNCT,AREA FISIOL E-33006 OVIEDO SPAIN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 59, anno: 1998,
pagine: 521 - 526
SICI:
0091-3057(1998)59:2<521:EOCAGO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER-INTAKE; ANGIOTENSIN-II; RATS; ESTROGEN; TESTOSTERONE; APPETITE; BRAIN;
Keywords:
WATER INTAKE; ESTROUS; TESTOSTERONE; ESTRADIOL; THIRST; ANGIOTENSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Fernandeztrisac et al., "EFFECT OF CASTRATION AND GONADAL-HORMONES ON INSULIN-INDUCED DRINKING", Pharmacology, biochemistry and behavior, 59(2), 1998, pp. 521-526

Abstract

Female Wistar rats in any of the estrual phases have been shown to drink significantly more water than males (p < 0.05), after a single IP insulin injection (5 U/kg b.wt.). Sexual differences in insulin-induced drinking persisted after castration when it was made in adult rats (4.6 +/- 1.2 ml/2 h, males = 8; vs. 13.0 +/- 3.1 ml/2 h, females = 8; p< 0.05). On the other hand, when animals were castrated before puberty or when newborn, sexual differences in insulin-induced drinking disappeared. Hence, insulin-induced drinking seems to be a sex-dependent phenomenon that differentiates just before or during puberty since it is abolished by castration prior to sexual maturation. Sex hormone administration in male and female rats castrated at different ages showed a variety of actions on insulin-induced drinking. A pattern emerged showing that androgenized (testosterone treated) rats drank usually lessin response to insulin than estrogen-treated rats (independent of their genetic sex). According to the above results, we can conclude that insulin-induced drinking is a phenomenon sensible to gonadal hormones,both by conditioning the differentiation of some physiological structure or mechanisms that underlay drinking behavior in that paradigm andby a direct action on these or other related mechanisms. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:24:05