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Titolo:
HIGH-CONCENTRATION OF GLUCOSE CAUSES IMPAIRMENT OF THE FUNCTION OF GLUTATHIONE REDOX CYCLE IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS
Autore:
TACHI Y; OKUDA Y; BANNAI C; OKAMURA N; BANNAI S; YAMASHITA K;
Indirizzi:
UNIV TSUKUBA,INST CLIN MED,DEPT ENDOCRINOL & METAB IBARAKI OSAKA 305 JAPAN UNIV TSUKUBA,INST CLIN MED,DEPT ENDOCRINOL & METAB IBARAKI OSAKA 305 JAPAN UNIV TSUKUBA,INST BASIC MED SCI,DEPT BIOCHEM IBARAKI OSAKA 305 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 421, anno: 1998,
pagine: 19 - 22
SICI:
0014-5793(1998)421:1<19:HOGCIO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; OXIDATIVE STRESS; TRANSPORT ACTIVITY; HYDROGEN-PEROXIDE; DIABETES-MELLITUS; HUMAN-FIBROBLASTS; FREE-RADICALS; METABOLISM; CYSTINE; INJURY;
Keywords:
H2O2; GLUTATHIONE; CYSTINE UPTAKE; HIGH GLUCOSE; HUMAN VASCULAR SMOOTH MUSCLE CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Tachi et al., "HIGH-CONCENTRATION OF GLUCOSE CAUSES IMPAIRMENT OF THE FUNCTION OF GLUTATHIONE REDOX CYCLE IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS", FEBS letters, 421(1), 1998, pp. 19-22

Abstract

We demonstrated that high glucose reduced H2O2? scavenge activity in human vascular smooth muscle cells, In the cells exposed to high glucose, the intracellular glutathione content decreased, although the NADPH content was unchanged, The rate of uptake of cystine, which is a rate-limiting precursor of the glutathione synthesis, decreased in the high glucose group compared with the control group, These decreases mereshown to be dependent on glucose concentration, It was suggested thathigh glucose causes impairment of the function of the glutathione redox cycle in human vascular smooth muscle cells, resulting in reduced H2O2 scavenge activity. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:43:08